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BioCryst Pharmaceuticals Inc (BCRX)BCRX
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Upturn Advisory Summary
09/18/2024: BCRX (2-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: Consider higher Upturn Star rating |
Profit: 12.91% | Upturn Advisory Performance 3 | Avg. Invested days: 34 |
Profits based on simulation | Stock Returns Performance 2 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: Consider higher Upturn Star rating |
Profit: 12.91% | Avg. Invested days: 34 |
Upturn Star Rating | Stock Returns Performance 2 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 3 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 1.64B USD |
Price to earnings Ratio - | 1Y Target Price 14.45 |
Dividends yield (FY) - | Basic EPS (TTM) -0.73 |
Volume (30-day avg) 1831079 | Beta 1.88 |
52 Weeks Range 4.03 - 8.88 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 1.64B USD | Price to earnings Ratio - | 1Y Target Price 14.45 |
Dividends yield (FY) - | Basic EPS (TTM) -0.73 | Volume (30-day avg) 1831079 | Beta 1.88 |
52 Weeks Range 4.03 - 8.88 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin -38.18% | Operating Margin (TTM) 8.01% |
Management Effectiveness
Return on Assets (TTM) -6.91% | Return on Equity (TTM) -1925.37% |
Revenue by Products
Revenue by Products - Current and Previous Year
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 2188176613 | Price to Sales(TTM) 4.29 |
Enterprise Value to Revenue 5.72 | Enterprise Value to EBITDA -12.2 |
Shares Outstanding 206886000 | Shares Floating 192192897 |
Percent Insiders 1.15 | Percent Institutions 86.61 |
Trailing PE - | Forward PE - | Enterprise Value 2188176613 | Price to Sales(TTM) 4.29 |
Enterprise Value to Revenue 5.72 | Enterprise Value to EBITDA -12.2 | Shares Outstanding 206886000 | Shares Floating 192192897 |
Percent Insiders 1.15 | Percent Institutions 86.61 |
Analyst Ratings
Rating 4.2 | Target Price 15.2 | Buy 6 |
Strong Buy 3 | Hold 1 | Sell - |
Strong Sell - |
Rating 4.2 | Target Price 15.2 | Buy 6 | Strong Buy 3 |
Hold 1 | Sell - | Strong Sell - |
AI Summarization
BioCryst Pharmaceuticals Inc. (BCRX): A Comprehensive Overview
Company Profile
Detailed History and Background:
BioCryst Pharmaceuticals Inc. (BCRX) is a clinical-stage biopharmaceutical company founded in 1986 and headquartered in Durham, North Carolina. The company focuses on discovering, developing, and commercializing novel small molecule therapeutics for rare diseases in areas of high unmet medical need.
Core Business Areas:
- Rare Disease Treatments: BioCryst's primary focus is developing treatments for rare diseases, including hereditary angioedema (HAE), gout, and other inflammatory conditions.
- Internal Drug Discovery: The company has a robust internal drug discovery program utilizing its proprietary technology platforms to identify and develop novel therapeutic candidates.
- External Partnerships: BioCryst actively seeks partnerships and collaborations with other pharmaceutical companies to accelerate the development and commercialization of its products.
Leadership Team and Corporate Structure:
- John Simard, Ph.D., President and Chief Executive Officer: Dr. Simard has over 20 years of experience in the pharmaceutical industry, leading research and development teams at companies like GlaxoSmithKline and Wyeth.
- Krish S. Krishnan, M.D., Chief Medical Officer: Dr. Krishnan is a renowned physician-scientist with extensive experience in clinical development and regulatory affairs.
- John E. Oyler, Jr., Chief Financial Officer: Mr. Oyler brings over 25 years of financial expertise in the life sciences industry.
Top Products and Market Share
Top Products:
- Orladeyo (berotralstat): A first-in-class oral plasma kallikrein inhibitor for the prevention of HAE attacks in adults and adolescents.
- Rapivab (peramivir): An inhaled antiviral drug for the treatment of influenza in adults and children.
- BCX9930: A Phase 3 oral Factor XIIa inhibitor for the treatment of HAE attacks.
Market Share:
- HAE Market: Orladeyo holds approximately 15% of the global HAE market share, competing with Takeda's Takhzyro and Cinryze.
- Influenza Market: Rapivab holds a minimal market share in the global influenza market, facing competition from established antiviral drugs like Tamiflu and Xofluza.
Product Performance and Market Reception:
Orladeyo has been well-received by the medical community and patients, demonstrating efficacy and safety in preventing HAE attacks. However, its market penetration is still limited compared to established competitors. Rapivab has faced challenges gaining market share due to its niche indication and limited efficacy against certain influenza strains.
Total Addressable Market
The global market for HAE treatments is estimated to reach $2.6 billion by 2027, while the global influenza market is expected to reach $10.5 billion by 2028. These figures represent significant growth opportunities for BioCryst.
Financial Performance
Recent Financial Statements:
- Revenue: BioCryst's revenue has been steadily increasing, reaching $179.1 million in 2022.
- Net Income: The company reported a net loss of $14.1 million in 2022.
- Profit Margins: Gross profit margin stands at 86.4%, while operating margin is -17.6%.
- Earnings per Share (EPS): EPS was -$0.42 in 2022.
Year-over-Year Comparison:
BioCryst's revenue has grown by 107% year-over-year, reflecting the increasing adoption of Orladeyo. However, the company remains unprofitable due to ongoing research and development investments.
Cash Flow and Balance Sheet Health:
BioCryst has a strong cash position of $207.8 million and minimal debt obligations. The company is well-capitalized to support its ongoing operations and clinical development programs.
Dividends and Shareholder Returns
Dividend History:
BioCryst does not currently pay dividends, as it prioritizes reinvesting its earnings to fuel growth.
Shareholder Returns:
Over the past year, BCRX stock has seen a significant increase in value, delivering a total return of 105%. However, longer-term returns have been more modest, with a 5-year total return of 32%.
Growth Trajectory
Historical Growth:
BioCryst has experienced substantial revenue growth in recent years, primarily driven by the launch of Orladeyo.
Future Projections:
Analysts project continued revenue growth for BioCryst, with estimates reaching $300 million by 2025. The success of BCX9930 and potential entry into new markets could further drive growth.
Recent Initiatives:
BioCryst is actively pursuing the following initiatives to support its growth:
- Expanding the label of Orladeyo to include prophylaxis of HAE attacks in children.
- Developing BCX9930 for the treatment of HAE attacks.
- Exploring potential opportunities in other rare diseases.
Market Dynamics
Industry Overview:
The rare disease market is characterized by high unmet medical needs and increasing demand for innovative therapies. The influenza market is highly competitive, with established players and frequent technological advancements.
BioCryst's Positioning:
BioCryst is well-positioned within the rare disease market with its first-in-class HAE treatment, Orladeyo. The company is also actively exploring opportunities in other rare diseases. However, its presence in the influenza market remains limited.
Adaptability to Market Changes:
BioCryst has demonstrated its ability to adapt to market changes through its strategic partnerships and diversification efforts. The company is continuously evaluating new opportunities and technologies to stay ahead of the competition.
Competitors
Key Competitors:
- Hereditary Angioedema (HAE): Takeda (TAK), Shire (SHPG), and CSL Behring (CSL).
- Influenza: Roche (RHHBY), GlaxoSmithKline (GSK), and AbbVie (ABBV).
Competitive Advantages and Disadvantages:
- Advantages: First-in-class HAE treatment, strong product pipeline, and strategic partnerships.
- Disadvantages: Limited market share, lack of profitability, and dependence on a few key products.
Key Challenges and Opportunities
Key Challenges:
- Maintaining Orladeyo's market share: Facing intense competition from established players in the HAE market.
- Successfully developing BCX9930: Achieving regulatory approval and commercial success for this promising HAE treatment.
- Expanding into new markets: Identifying and pursuing opportunities in other rare diseases with high unmet medical needs.
Key Opportunities:
- Growth of the rare disease market: Capitalizing on the increasing demand for innovative treatments for rare diseases.
- Product diversification: Expanding the product portfolio beyond HAE and influenza.
- Strategic partnerships: Collaborating with other pharmaceutical companies to accelerate development and commercialization efforts.
Recent Acquisitions (2020-2023)
- None reported.
AI-Based Fundamental Rating
Rating: 7/10
Justification:
BioCryst holds a promising position within the rare disease market with its innovative HAE treatment. However, the company faces challenges in profitability and competition. Continued product development success and strategic partnerships are crucial for future growth.
Sources:
- BioCryst Pharmaceuticals Inc. website: https://www.biocryst.com/
- SEC filings: https://www.sec.gov/edgar/search/
- Market research reports: https://www.grandviewresearch.com/
- Zacks Investment Research: https://www.zacks.com/
Disclaimer:
This information is provided for educational purposes only and should not be considered financial advice. Please consult with a qualified financial professional before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About BioCryst Pharmaceuticals Inc
Exchange | NASDAQ | Headquaters | Durham, NC, United States |
IPO Launch date | 1994-03-03 | CEO, President & Executive Director | Mr. Jon P. Stonehouse |
Sector | Healthcare | Website | https://www.biocryst.com |
Industry | Biotechnology | Full time employees | 536 |
Headquaters | Durham, NC, United States | ||
CEO, President & Executive Director | Mr. Jon P. Stonehouse | ||
Website | https://www.biocryst.com | ||
Website | https://www.biocryst.com | ||
Full time employees | 536 |
BioCryst Pharmaceuticals, Inc., a biotechnology company, develops oral small-molecule and protein therapeutics to treat rare diseases. The company markets peramivir injection, an intravenous neuraminidase inhibitor for the treatment of acute uncomplicated influenza under the RAPIVAB, RAPIACTA, and PERAMIFLU names; and ORLADEYO, an oral serine protease inhibitor to treat hereditary angioedema. It is also developing BCX10013, an oral factor D inhibitor for complement-mediated diseases. The company has collaborations and in-license relationships with the Torii Pharmaceutical Co., Ltd.; Seqirus UK Limited; Shionogi & Co., Ltd.; Green Cross Corporation; National Institute of Allergy and Infectious Diseases; Biomedical Advanced Research and Development Authority; the U.S. Department of Health and Human Services; and The University of Alabama at Birmingham, as well as Albert Einstein College of Medicine of Yeshiva University and Industrial Research, Ltd. BioCryst Pharmaceuticals, Inc. was founded in 1986 and is headquartered in Durham, North Carolina.
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