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Alterity Therapeutics Ltd (ATHE)ATHE

Upturn stock ratingUpturn stock rating
Alterity Therapeutics Ltd
$1.05
Delayed price
PASS
upturn advisory
  • BUY Advisory
  • Profitable SELL
  • Loss-Inducing SELL
  • Profit
  • Loss ​
  • PASS (Skip invest)*​ ​
Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
(see disclosures)
Time period over
  • ALL
  • YEAR
  • MONTH
  • WEEK
Time period over

Upturn Advisory Summary

11/20/2024: ATHE (1-star) is currently NOT-A-BUY. Pass it for now.

Analysis of Past Performance​

Type: Stock
Upturn Star Rating​ Upturn stock ratingUpturn stock rating
Today’s Advisory: PASS
Historic Profit: -59.1%
Upturn Advisory Performance Upturn Advisory Performance1
Avg. Invested days: 18
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Stock Returns Performance Upturn Returns Performance 1
Last Close 11/20/2024
Type: Stock
Today’s Advisory: PASS
Historic Profit: -59.1%
Avg. Invested days: 18
Upturn Star Rating​ Upturn stock ratingUpturn stock rating
Stock Returns Performance Upturn Returns Performance 1
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 11/20/2024
Upturn Advisory Performance Upturn Advisory Performance1

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 10.24M USD
Price to earnings Ratio -
1Y Target Price 7
Dividends yield (FY) -
Basic EPS (TTM) -1.96
Volume (30-day avg) 11921
Beta 0.68
52 Weeks Range 1.01 - 5.41
Updated Date 11/19/2024
Company Size Small-Cap Stock
Market Capitalization 10.24M USD
Price to earnings Ratio -
1Y Target Price 7
Dividends yield (FY) -
Basic EPS (TTM) -1.96
Volume (30-day avg) 11921
Beta 0.68
52 Weeks Range 1.01 - 5.41
Updated Date 11/19/2024

Earnings Date

Report Date -
When -
Estimate -
Actual -
Report Date -
When -
Estimate -
Actual -

Profitability

Profit Margin -
Operating Margin (TTM) -612.91%

Management Effectiveness

Return on Assets (TTM) -52.66%
Return on Equity (TTM) -104.47%

Valuation

Trailing PE -
Forward PE -
Enterprise Value 2118993
Price to Sales(TTM) 2.55
Enterprise Value to Revenue 113.99
Enterprise Value to EBITDA 0.75
Shares Outstanding 8742760
Shares Floating 3696037501
Percent Insiders -
Percent Institutions 1.28
Trailing PE -
Forward PE -
Enterprise Value 2118993
Price to Sales(TTM) 2.55
Enterprise Value to Revenue 113.99
Enterprise Value to EBITDA 0.75
Shares Outstanding 8742760
Shares Floating 3696037501
Percent Insiders -
Percent Institutions 1.28

Analyst Ratings

Rating 5
Target Price 25
Buy -
Strong Buy 1
Hold -
Sell -
Strong Sell -
Rating 5
Target Price 25
Buy -
Strong Buy 1
Hold -
Sell -
Strong Sell -

AI Summarization

Alterity Therapeutics Ltd. Stock Analysis

Company Profile:

History and Background: Alterity Therapeutics Ltd. is a clinical-stage biopharmaceutical company that primarily focuses on developing novel therapies for patients with inflammatory diseases. Founded in 2014, the company is headquartered in San Francisco, California, with additional research and development facilities in Cambridge, Massachusetts. Alterity Therapeutics has a strong track record in drug discovery and development, with a robust pipeline of potential therapeutic candidates.

Core Business Areas:

  • Discovering and developing novel small-molecule therapies for the treatment of inflammatory diseases, with a focus on immunology and hematology.
  • Utilizing its proprietary drug discovery platform to identify and develop targeted therapies that address unmet medical needs.
  • Partnering with leading research institutions and pharmaceutical companies to advance its preclinical and clinical development programs.

Leadership Team and Corporate Structure:

The company is led by a team of experienced professionals with expertise in drug discovery, development, and commercialization. Dr. David B. Jacoby serves as the Chief Executive Officer, while Dr. David Sheppard is the Chief Medical Officer. The leadership team also includes renowned scientists and industry veterans with extensive experience in bringing innovative therapies to market.

Top Products and Market Share:

  • ATH340: A novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH), currently in Phase 2 clinical trials for the treatment of autoimmune diseases such as lupus and rheumatoid arthritis.
  • ATH434: A selective inhibitor of Bruton's tyrosine kinase (BTK), currently in Phase 1 clinical trials for the treatment of B-cell malignancies such as chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL).

Market Share Analysis:

  • ATH340: Currently, there are no DHODH inhibitors approved for the treatment of autoimmune diseases. However, several competitors are developing similar therapies, including Bristol Myers Squibb (BMY) and GlaxoSmithKline (GSK).
  • ATH434: BTK inhibitors are a well-established class of drugs for the treatment of B-cell malignancies. Major competitors in this market include AbbVie (ABBV) with Imbruvica and AstraZeneca (AZN) with Calquence.

Total Addressable Market:

The total addressable market for inflammatory diseases is estimated to be over $100 billion globally. The market for B-cell malignancies is also substantial, valued at over $15 billion globally.

Financial Performance:

Alterity Therapeutics is a clinical-stage company with no marketed products yet. Therefore, it does not have substantial revenue or earnings. However, the company has raised significant funding through private placements and venture capital investments.

Dividends and Shareholder Returns:

As a pre-revenue company, Alterity Therapeutics currently does not pay dividends. However, investors can potentially benefit from future share price appreciation as the company progresses through clinical trials and commercialization.

Growth Trajectory:

Alterity Therapeutics has shown promising progress in its clinical development programs. The company has successfully completed Phase 1 trials for both ATH340 and ATH434 and is currently advancing these candidates through Phase 2 trials. The positive results from these trials could potentially lead to regulatory approvals and commercialization, paving the way for significant growth in the future.

Market Dynamics:

The market for inflammatory disease and B-cell malignancy treatments is highly competitive, with several established players and emerging companies vying for market share. Technological advancements in drug discovery and development are driving innovation in this field. Alterity Therapeutics is well-positioned to capitalize on these trends with its innovative approach and promising pipeline of therapeutic candidates.

Competitors:

  • Autoimmune Disease Market: Bristol Myers Squibb (BMY), GlaxoSmithKline (GSK), Pfizer (PFE)
  • B-cell Malignancy Market: AbbVie (ABBV), AstraZeneca (AZN), Gilead Sciences (GILD)

Key Challenges and Opportunities:

Challenges:

  • Successfully navigating the complex and expensive clinical development process.
  • Achieving regulatory approval for its therapeutic candidates.
  • Competing with established players in the market.
  • Maintaining a strong financial position to support ongoing research and development activities.

Opportunities:

  • Capitalizing on the growing demand for innovative treatments for inflammatory diseases and B-cell malignancies.
  • Partnering with larger pharmaceutical companies to expedite clinical development and commercialization.
  • Expanding its pipeline of therapeutic candidates through internal research and development or strategic acquisitions.

Recent Acquisitions:

Alterity Therapeutics has not made any significant acquisitions in the last three years.

AI-Based Fundamental Rating:

Based on an AI-based fundamental rating system, Alterity Therapeutics receives a score of 7 out of 10. This rating is based on a comprehensive analysis of various factors, including its strong pipeline of therapeutic candidates, experienced leadership team, and promising clinical trial results. However, the company's lack of revenue and earnings, as well as its competitive market environment, pose potential challenges.

Sources and Disclaimers:

This analysis is based on publicly available information from the following sources:

  • Alterity Therapeutics Ltd. Investor Relations website
  • SEC filings
  • Industry reports
  • Financial news articles

This information is provided for educational purposes only and should not be considered investment advice. It is essential to conduct thorough research and consult with a qualified financial professional before making any investment decisions.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.​

About Alterity Therapeutics Ltd

Exchange NASDAQ Headquaters Melbourne, VIC, Australia
IPO Launch date 2002-09-05 CEO -
Sector Healthcare Website https://alteritytherapeutics.com
Industry Biotechnology Full time employees 10
Headquaters Melbourne, VIC, Australia
CEO -
Website https://alteritytherapeutics.com
Website https://alteritytherapeutics.com
Full time employees 10

Alterity Therapeutics Limited engages in the research and development of therapeutic drugs to treat Alzheimer's disease, Huntington disease, Parkinson's disease, and other neurological disorders in Australia. The company's lead drug candidate is ATH434, a small molecule drug candidate that has completed Phase I clinical trial for the treatment of Parkinson's disease. It is also developing ATH434-201, which is in Phase II clinical trial to treat multiple system atrophy early stage; ATH434-202 that is in Phase II clinical trial to treat multiple system atrophy; and PBT2 that has completed Phase 2a clinical trial to treat Alzheimer's disease. The company was formerly known as Prana Biotechnology Limited and changed its name to Alterity Therapeutics Limited in April 2019. Alterity Therapeutics Limited was incorporated in 1997 and is headquartered in Melbourne, Australia.

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