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Assembly Biosciences Inc (ASMB)ASMB

Upturn stock ratingUpturn stock rating
Assembly Biosciences Inc
$16.93
Delayed price
PASS
upturn advisory
  • BUY Advisory
  • Profitable SELL
  • Loss-Inducing SELL
  • Profit
  • Loss ​
  • PASS (Skip invest)*​ ​
Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
(see disclosures)
Time period over
  • ALL
  • YEAR
  • MONTH
  • WEEK
Time period over

Upturn Advisory Summary

10/24/2024: ASMB (1-star) is currently NOT-A-BUY. Pass it for now.

Analysis of Past Performance​

Type: Stock
Upturn Star Rating​ Upturn stock ratingUpturn stock rating
Today’s Advisory: PASS
Historic Profit: -46.62%
Upturn Advisory Performance Upturn Advisory Performance2
Avg. Invested days: 29
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Stock Returns Performance Upturn Returns Performance 1
Last Close 10/24/2024
Type: Stock
Today’s Advisory: PASS
Historic Profit: -46.62%
Avg. Invested days: 29
Upturn Star Rating​ Upturn stock ratingUpturn stock rating
Stock Returns Performance Upturn Returns Performance 1
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 10/24/2024
Upturn Advisory Performance Upturn Advisory Performance2

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 97.51M USD
Price to earnings Ratio -
1Y Target Price 35.5
Dividends yield (FY) -
Basic EPS (TTM) -6.89
Volume (30-day avg) 36891
Beta 0.59
52 Weeks Range 8.22 - 19.93
Updated Date 11/20/2024
Company Size Small-Cap Stock
Market Capitalization 97.51M USD
Price to earnings Ratio -
1Y Target Price 35.5
Dividends yield (FY) -
Basic EPS (TTM) -6.89
Volume (30-day avg) 36891
Beta 0.59
52 Weeks Range 8.22 - 19.93
Updated Date 11/20/2024

Earnings Date

Report Date 2024-11-06
When AfterMarket
Estimate -2.02
Actual -1.51
Report Date 2024-11-06
When AfterMarket
Estimate -2.02
Actual -1.51

Profitability

Profit Margin -212.33%
Operating Margin (TTM) -143.01%

Management Effectiveness

Return on Assets (TTM) -34.72%
Return on Equity (TTM) -101.78%

Valuation

Trailing PE -
Forward PE -
Enterprise Value 3993427
Price to Sales(TTM) 4.54
Enterprise Value to Revenue 0.14
Enterprise Value to EBITDA 0.42
Shares Outstanding 6356290
Shares Floating 3825485
Percent Insiders 31.62
Percent Institutions 18.79
Trailing PE -
Forward PE -
Enterprise Value 3993427
Price to Sales(TTM) 4.54
Enterprise Value to Revenue 0.14
Enterprise Value to EBITDA 0.42
Shares Outstanding 6356290
Shares Floating 3825485
Percent Insiders 31.62
Percent Institutions 18.79

Analyst Ratings

Rating 4.33
Target Price 3
Buy -
Strong Buy 2
Hold 1
Sell -
Strong Sell -
Rating 4.33
Target Price 3
Buy -
Strong Buy 2
Hold 1
Sell -
Strong Sell -

AI Summarization

Assembly Biosciences Inc. Comprehensive Overview

Company Profile

Detailed history and background:

Assembly Biosciences Inc. (ASSM) is a clinical-stage biotechnology company founded in 2013 and headquartered in San Francisco, California. The company focuses on developing innovative therapeutics for chronic viral diseases, primarily hepatitis B virus (HBV) and chronic delta hepatitis (HDV). ASSM leverages its expertise in virology, genomics, and drug discovery to create novel therapies with the potential to cure these diseases.

Core business areas:

  • HBV and HDV therapeutics: Developing oral therapies for the treatment of HBV and HDV infections.
  • Other viral targets: Exploring potential applications of ASSM's technology platform for other chronic viral diseases.

Leadership team and corporate structure:

  • John McHutchison, MD, President and CEO: Seasoned leader with over 25 years of experience in the pharmaceutical industry, including leading Gilead's antiviral development and commercialization.
  • Patrick O'Gara, CFO: Extensive finance and accounting experience in the healthcare industry.
  • Dr. John Alam, MD, PhD, Chief Development Officer: Expert in infectious diseases with over 15 years of experience in research and development.
  • Board of Directors: Comprises experienced industry professionals with expertise in finance, life sciences, and medicine.

Top Products and Market Share

Top products and offerings:

  • Assembly Biosciences does not currently have any marketed products. The company's pipeline consists of investigational therapies in various stages of development, including:
    • ABI-H0731: A next-generation oral capsid inhibitor for chronic HBV infection.
    • ABI-H2158: A novel oral RNA interference (RNAi) therapeutic for chronic HBV and HDV infection.
    • Other HBV and HDV therapies: The company is exploring additional therapeutic approaches, including combination therapies and gene editing.

Market share analysis:

  • As Assembly Biosciences has no marketed products, it currently holds no market share. However, the company's HBV and HDV treatments target a significant market:
    • HBV: The global HBV market is estimated to reach $4.4 billion by 2027, with a CAGR of 7.5%.
    • HDV: The global HDV market is estimated to reach $3.6 billion by 2027, with a CAGR of 8.2%.

Product performance and market reception:

  • ABI-H0731 has demonstrated promising results in Phase 2a clinical trials, achieving significant reductions in HBV viral load.
  • ABI-H2158 is currently in Phase 1b clinical trials for both HBV and HDV infection.
  • Early data suggest potential for long-term suppression of viral markers, although further clinical development is necessary.

Total Addressable Market

The total addressable market for Assembly Biosciences' HBV and HDV treatments is substantial:

  • Global HBV market: Over 300 million people infected with chronic HBV worldwide.
  • Global HDV market: Estimated 5 million people infected with HDV, primarily co-infected with HBV.

Financial Performance

Recent financial performance:

  • Revenue: No product sales yet, as the company is in the clinical development stage.
  • Net income: Net losses incurred due to R&D expenses and general operating costs.
  • Profit margins: Not applicable, as the company is not yet profitable.
  • EPS: Negative earnings per share.

Financial performance comparison:

  • Year-over-year revenue growth is negative due to the absence of product sales.
  • Net losses have been declining in recent quarters, reflecting cost optimization efforts.

Cash flow and balance sheet:

  • The company has a strong cash position thanks to recent financing rounds, providing runway for ongoing clinical development.
  • The balance sheet shows a significant portion of assets dedicated to research and development activities.

Dividends and Shareholder Returns

  • Dividend History: Assembly Biosciences does not currently offer dividends, as it is focused on reinvesting earnings into R&D.
  • Shareholder Returns: The stock price has experienced volatility due to its early-stage development focus, and long-term shareholder returns are primarily driven by future commercial success of its pipeline products.

Growth Trajectory

Historical growth analysis:

  • The company has experienced significant growth in R&D spending and investments in its pipeline.
  • Clinical progress and data releases have driven stock price fluctuations.

Future growth projections:

  • Market potential for HBV and HDV treatments is significant.
  • Success of clinical trials and potential product approvals could drive significant revenue growth and stock price appreciation.
  • Continued R&D investment and strategic partnerships will be crucial for achieving long-term growth objectives.

Market Dynamics

Industry overview:

  • The antiviral market is experiencing rapid growth due to increasing awareness and prevalence of chronic viral diseases.
  • Technological advancements, such as gene editing and RNAi, are driving innovation in the development of novel therapies.
  • Competition is intense, with numerous pharmaceutical companies and biotech startups vying for market share.

Assembly's market position and adaptability:

  • Assembly Biosciences holds a differentiated position with its focus on novel therapies for HBV and HDV.
  • The company actively invests in R&D and strategic partnerships to stay ahead of the competitive landscape.
  • Adaptability to market changes will be crucial for success, considering the evolving regulatory landscape and technological advancements.

Competitors

Key competitors:

  • Gilead Sciences (GILD)
  • Bristol Myers Squibb (BMY)
  • AbbVie (ABBV)
  • Intercept Pharmaceuticals (ICPT)

Market share comparison:

  • As Assembly Biosciences has no marketed products, it does not hold market share yet. However, their competitors hold significant market shares in the HBV market:
    • Gilead Sciences: Holds a dominant position with its HBV treatment, Vemlidy.
    • Other competitors share the remaining market share, with individual market shares varying depending on specific product offerings.

Competitive advantages and disadvantages:

  • Advantages:
    • Novel technology platform with potential for best-in-class therapies.
    • Experienced leadership team with proven track record in drug development.
    • Strong financial position to support ongoing clinical trials.
  • Disadvantages:
    • Early-stage development pipeline with limited clinical data.
    • Intense competition from established players in the industry.
    • Regulatory risks associated with drug development and approval.

Potential Challenges and Opportunities

Key challenges:

  • Demonstrating clinical efficacy and safety of pipeline candidates.
  • Successfully navigating the regulatory approval process.
  • Achieving commercial success and market penetration in a competitive landscape.
  • Managing R&D expenses and maintaining financial runway.

Potential opportunities:

  • Addressing unmet medical needs in HBV and HDV treatment with novel and potentially curative therapies.
  • Capitalizing on the growing global market for antiviral treatments.
  • Leveraging strategic partnerships to accelerate development and commercialization efforts.
  • Exploring additional applications of the company's technology platform for other viral diseases.

Recent Acquisitions (last 3 years)

Assembly Biosciences has not made any acquisitions in the last 3 years.

AI-Based Fundamental Rating

Rating: 7 out of 10

Justification:

  • Strengths:
    • Promising pipeline with potential for first-in-class therapies.
    • Experienced leadership team with strong industry track record.
    • Strong financial position for ongoing development activities.
  • Weaknesses:
    • Early-stage development pipeline with limited clinical data.
    • Intense competition from established players in the industry.
    • Regulatory risks associated with drug development and approval.

Disclaimer:

The information provided in this report is based on publicly available data and should not be considered financial advice. It is recommended to consult with a qualified financial professional before making investment decisions.

Sources

I hope this detailed overview provides a comprehensive understanding of Assembly Biosciences Inc.'s current standing, market position, and future potential.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.​

About Assembly Biosciences Inc

Exchange NASDAQ Headquaters South San Francisco, CA, United States
IPO Launch date 2010-12-17 CEO, President & Director Mr. Jason A. Okazaki
Sector Healthcare Website https://www.assemblybio.com
Industry Biotechnology Full time employees 65
Headquaters South San Francisco, CA, United States
CEO, President & Director Mr. Jason A. Okazaki
Website https://www.assemblybio.com
Website https://www.assemblybio.com
Full time employees 65

Assembly Biosciences, Inc., a biotechnology company, develops therapeutic candidates for the treatment of viral diseases. It develops ABI-5366, a long-acting herpes simplex virus (HSV) helicase-primase inhibitor that is in Phase 1a/1b clinical trial to treat recurrent genital herpes; ABI-1179, which is in Phase 1a/1b clinical trial for the treatment of recurrent genital herpes; and ABI-6250, a small molecule orally bioavailable hepatitis delta virus entry inhibitor that is in Phase 1a clinical trial. The company also develops ABI-4334, a next-generation capsid assembly modulator, which is in Phase 1b clinical trial for the treatment of hepatitis B virus (HBV). In addition, it develops an oral non-nucleoside polymerase inhibitor targeting transplant-related herpesviruses; and a small molecule interferon-a receptor agonist targeting HBV and HDV. The company has collaboration agreements with Gilead Sciences, Inc. and BeiGene, Ltd. The company was formerly known as Ventrus Biosciences, Inc. and changed its name to Assembly Biosciences, Inc. in June 2014. Assembly Biosciences, Inc. was incorporated in 2005 and is headquartered in South San Francisco, California.

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