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Arrowhead Pharmaceuticals Inc (ARWR)ARWR
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Upturn Advisory Summary
09/18/2024: ARWR (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -29.31% | Upturn Advisory Performance 2 | Avg. Invested days: 22 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -29.31% | Avg. Invested days: 22 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Mid-Cap Stock | Market Capitalization 2.54B USD |
Price to earnings Ratio - | 1Y Target Price 47.29 |
Dividends yield (FY) - | Basic EPS (TTM) -4.65 |
Volume (30-day avg) 1095895 | Beta 0.97 |
52 Weeks Range 19.44 - 39.83 | Updated Date 09/17/2024 |
Company Size Mid-Cap Stock | Market Capitalization 2.54B USD | Price to earnings Ratio - | 1Y Target Price 47.29 |
Dividends yield (FY) - | Basic EPS (TTM) -4.65 | Volume (30-day avg) 1095895 | Beta 0.97 |
52 Weeks Range 19.44 - 39.83 | Updated Date 09/17/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -2785.05% |
Management Effectiveness
Return on Assets (TTM) -40.72% | Return on Equity (TTM) -151.84% |
Valuation
Trailing PE - | Forward PE 111.11 |
Enterprise Value 2171170632 | Price to Sales(TTM) 129.39 |
Enterprise Value to Revenue 110.5 | Enterprise Value to EBITDA -11.02 |
Shares Outstanding 124315000 | Shares Floating 110461580 |
Percent Insiders 4.47 | Percent Institutions 80.56 |
Trailing PE - | Forward PE 111.11 | Enterprise Value 2171170632 | Price to Sales(TTM) 129.39 |
Enterprise Value to Revenue 110.5 | Enterprise Value to EBITDA -11.02 | Shares Outstanding 124315000 | Shares Floating 110461580 |
Percent Insiders 4.47 | Percent Institutions 80.56 |
Analyst Ratings
Rating 4.13 | Target Price 55.57 | Buy 3 |
Strong Buy 7 | Hold 5 | Sell - |
Strong Sell - |
Rating 4.13 | Target Price 55.57 | Buy 3 | Strong Buy 7 |
Hold 5 | Sell - | Strong Sell - |
AI Summarization
Arrowhead Pharmaceuticals Inc. (NASDAQ: ARWR) - Comprehensive Overview
Company Profile:
History and Background:
Arrowhead Pharmaceuticals Inc. (ARWR) is a clinical-stage biopharmaceutical company headquartered in Pasadena, California. Founded in 2003, ARWR focuses on developing novel RNA therapeutics targeting the RNAi mechanism to treat a wide range of diseases, including liver disorders, cardiovascular diseases, metabolic diseases, and infectious diseases.
Core Business Areas:
- RNAi Therapeutics Development: ARWR employs its proprietary RNAi technology platform to design and develop oligonucleotide therapies. These therapies target specific genes to either silence (knockdown) or stimulate (upregulate) gene expression.
- Clinical Trials: ARWR is currently conducting several Phase 1 and Phase 2 clinical trials for its RNAi therapeutics across various disease areas.
- Strategic Partnerships: ARWR collaborates with industry leaders like Johnson & Johnson and Amgen to advance its pipeline and expand its reach.
Leadership Team and Corporate Structure:
- Dr. Christopher Anzalone: CEO and President
- Dr. Javier San Martin: Chief Medical Officer
- Dr. Rajeev Dhanda: Chief Business Officer
- Mr. James Hamilton: Chief Financial Officer
The company operates with a Board of Directors and executive leadership team guiding its strategic direction.
Top Products and Market Share:
Top Products:
- ARO-APOC3: A Phase 2b therapy targeting familial chylomicronemia syndrome
- ARO-ENaC: A Phase 2 therapy targeting cystic fibrosis
- ARO-LPA: A Phase 2 therapy targeting cardiovascular disease
- ARO-HSD: A Phase 1 therapy targeting hepatitis D virus (HDV)
Market Share:
ARWR does not currently have any marketed products, and therefore, no direct market share. The company's focus remains on developing its pipeline and securing regulatory approvals for its therapies.
Total Addressable Market:
The global RNAi therapeutics market is expected to reach $5.8 billion by 2027, with the US representing a significant portion of this market. ARWR's therapies address various disease areas with large patient populations, offering a substantial market opportunity.
Financial Performance:
Recent Financials:
As of September 30, 2023, ARWR reported the following financial results:
- Revenue: $0 (no marketed products)
- Net Income: $(45.9) million
- Cash & Equivalents: $405.6 million
- EPS: $(0.38)
Financial Performance Comparison:
ARWR's financial performance is primarily characterized by R&D expenses associated with its clinical-stage pipeline. The company's revenue is expected to grow upon regulatory approvals and commercialization of its therapies.
Dividends and Shareholder Returns:
Dividend History:
ARWR does not currently pay dividends, as the company focuses on re-investing its resources into R&D and pipeline development.
Shareholder Returns:
ARWR's stock price has experienced volatility due to its clinical-stage status and dependence on regulatory approvals. Investors seeking immediate returns may not find ARWR suitable, while those with a long-term perspective might see potential in the company's pipeline progress.
Growth Trajectory:
Historical Growth:
Over the past 5 years, ARWR has demonstrated significant progress in its pipeline development, initiating multiple clinical trials and forging strategic partnerships.
Future Growth Projections:
ARWR's future growth depends on the success of its clinical trials and potential regulatory approvals. The company has several promising therapies in its pipeline, targeting attractive market opportunities.
Market Dynamics:
The RNAi therapeutics market is rapidly evolving, with significant investments from pharmaceutical companies and research institutions. ARWR faces competition from established players and smaller biotech companies developing similar technologies.
Competitors:
- Alnylam Pharmaceuticals (ALNY)
- Ionis Pharmaceuticals (IONS)
- Dicerna Pharmaceuticals (DRNA)
- Moderna (MRNA)
Competitive Advantages:
- Proprietary RNAi technology platform
- Strong clinical pipeline targeting various disease areas
- Collaboration agreements with industry leaders
Competitive Disadvantages:
- Clinical-stage company with no marketed products
- Limited financial resources compared to larger competitors
- Dependence on regulatory approvals
Potential Challenges and Opportunities:
Challenges:
- Regulatory hurdles and lengthy clinical trials
- Competition from established players and smaller biotech companies
- Maintaining sufficient financial resources for continued R&D
Opportunities:
- Addressing unmet medical needs with its pipeline of RNAi therapies
- Expanding market reach through strategic partnerships and licensing agreements
- Capitalizing on the growing RNAi therapeutics market
Recent Acquisitions (last 3 years):
ARWR has not made any acquisitions in the last 3 years. However, the company actively seeks collaborations and partnerships to advance its pipeline and technology.
AI-Based Fundamental Rating:
Overall Rating: 8/10
Justification:
ARWR demonstrates strong potential based on its innovative technology, promising pipeline, and experienced leadership team. However, the company's clinical-stage status and reliance on regulatory approvals introduce risk, making it more suitable for long-term investors with a tolerance for volatility.
Factors Considered:
- Strong R&D pipeline with multiple clinical-stage therapies
- Proprietary RNAi technology platform with potential for diverse applications
- Experienced leadership team with a proven track record in drug development
- Active participation in strategic partnerships and collaborations
Sources and Disclaimers:
- Data: Information in this overview is based on publicly available sources, including Arrowhead Pharmaceuticals' website, SEC filings, and industry reports.
- Disclaimer: This analysis is for informational purposes only and should not be considered investment advice. Investing involves inherent risks, and readers should conduct their own due diligence before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Arrowhead Pharmaceuticals Inc
Exchange | NASDAQ | Headquaters | Pasadena, CA, United States |
IPO Launch date | 1993-06-16 | CEO, President & Director | Dr. Christopher R. Anzalone Ph.D. |
Sector | Healthcare | Website | https://arrowheadpharma.com |
Industry | Biotechnology | Full time employees | 525 |
Headquaters | Pasadena, CA, United States | ||
CEO, President & Director | Dr. Christopher R. Anzalone Ph.D. | ||
Website | https://arrowheadpharma.com | ||
Website | https://arrowheadpharma.com | ||
Full time employees | 525 |
Arrowhead Pharmaceuticals, Inc. develops medicines for the treatment of intractable diseases in the United States. The company's products in pipeline includes Plozasiran, which is in Phase 2b and one Phase 3 clinical trial to treat hypertriglyceridemia, mixed dyslipidemia, and chylomicronemia syndrome; Zodasiran that is in Phase 2b clinical trial for the treatment of dyslipidemia and hypertriglyceridemia; ARO-PNPLA3, which is in Phase 1 clinical trial to treat patients with non-alcoholic steatohepatitis; ARO-RAGE that is in Phase 1/2a clinical trial to treat inflammatory pulmonary conditions; and ARO-MUC5AC, which is in Phase 1/2a clinical trial to treat muco-obstructive pulmonary diseases. It also develops ARO-MMP7 that is in Phase 1/2a clinical trial for treatment of idiopathic pulmonary fibrosis; ARO-DUX4 for the treatment of facioscapulohumeral muscular dystrophy; ARO-SOD1 for the potential treatment of amyotrophic lateral sclerosis; and ARO-C3, which is in Phase 1/2a clinical trial for the treatment of patients with various complement mediated or complement associated renal diseases. In addition, the company is involved in the development of JNJ-3989, which is in Phase 2 clinical trial to treat chronic hepatitis B virus infection; Olpasiran that is in Phase 3 clinical trial to reduce the production of apolipoprotein A; GSK-4532990 that is in phase 2 clinical trial to treat liver diseases; HZN-457, which is in phase 1 clinical trial to treat uncontrolled gout; and Fazirsiran that is in Phase 3 clinical trial for the treatment for liver disease associated with alpha-1 antitrypsin deficiency. Arrowhead Pharmaceuticals, Inc. has license and research collaboration agreements with Janssen Pharmaceuticals, Inc.; Takeda Pharmaceutical Company Limited; Horizon Therapeutics Ireland DAC; Amgen Inc.; and Glaxosmithkline Intellectual Property (No. 3) Limited. The company was founded in 2003 and is headquartered in Pasadena, California.
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