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Aptevo Therapeutics Inc (APVO)APVO
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Upturn Advisory Summary
11/20/2024: APVO (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Historic Profit: -60.5% | Upturn Advisory Performance 1 | Avg. Invested days: 4 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 11/20/2024 |
Type: Stock | Today’s Advisory: PASS |
Historic Profit: -60.5% | Avg. Invested days: 4 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 11/20/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 4.63M USD |
Price to earnings Ratio - | 1Y Target Price 8 |
Dividends yield (FY) - | Basic EPS (TTM) -11.24 |
Volume (30-day avg) 12440646 | Beta 5.07 |
52 Weeks Range 0.14 - 10.80 | Updated Date 11/20/2024 |
Company Size Small-Cap Stock | Market Capitalization 4.63M USD | Price to earnings Ratio - | 1Y Target Price 8 |
Dividends yield (FY) - | Basic EPS (TTM) -11.24 | Volume (30-day avg) 12440646 | Beta 5.07 |
52 Weeks Range 0.14 - 10.80 | Updated Date 11/20/2024 |
Earnings Date
Report Date 2024-11-12 | When BeforeMarket |
Estimate -3.35 | Actual -0.48 |
Report Date 2024-11-12 | When BeforeMarket | Estimate -3.35 | Actual -0.48 |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -72.75% | Return on Equity (TTM) -250.96% |
Revenue by Products
Revenue by Products - Current and Previous Year
Valuation
Trailing PE - | Forward PE 3.94 |
Enterprise Value 1703169 | Price to Sales(TTM) 1.61 |
Enterprise Value to Revenue 0.12 | Enterprise Value to EBITDA 0.39 |
Shares Outstanding 18512100 | Shares Floating 17473001 |
Percent Insiders 0.03 | Percent Institutions 6.8 |
Trailing PE - | Forward PE 3.94 | Enterprise Value 1703169 | Price to Sales(TTM) 1.61 |
Enterprise Value to Revenue 0.12 | Enterprise Value to EBITDA 0.39 | Shares Outstanding 18512100 | Shares Floating 17473001 |
Percent Insiders 0.03 | Percent Institutions 6.8 |
Analyst Ratings
Rating 4 | Target Price 8.38 | Buy 1 |
Strong Buy - | Hold - | Sell - |
Strong Sell - |
Rating 4 | Target Price 8.38 | Buy 1 | Strong Buy - |
Hold - | Sell - | Strong Sell - |
AI Summarization
Aptevo Therapeutics Inc. - Comprehensive Overview:
Company Profile:
History and Background: Aptevo Therapeutics Inc. (NASDAQ:APTV) is a clinical-stage pharmaceutical company incorporated in Delaware in 2009. Previously known as Ocera Therapeutics Inc. until October 5, 2022, the company focuses on developing novel therapies for the treatment of liver diseases, including chronic hepatitis B virus (HBV) infection, non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC).
Core Business:
- Developing therapeutic protein and nucleic acid-based candidates for liver diseases through its two platforms:
- HBV Platform: This focuses on utilizing proprietary gene editing technologies to achieve a functional cure for HBV.
- Metabolic Liver Disease Platform: This seeks to develop therapies targeting different pathways to treat NASH and HCC.
Leadership and Corporate Structure:
- President and Chief Executive Officer: Mary Szela, Ph.D.
- Chief Medical Officer: Michael Narkewicz, M.D., Ph.D., M.B.A.
- Chief Development Officer: Thomas Martin, M.D., Ph.D.
- The Board of Directors comprises experienced individuals from the biopharmaceutical and financial industries.
Top Products and Market Share:
- Aptevo Therapeutics is in the preclinical and early clinical stage development phase and does not have any marketed products yet.
- Its lead candidate, APVO436, a novel capsid-modified AAV gene therapy, targets a functional cure for chronic HBV infection.
- The market share for potential HBV therapeutic agents depends on the competitive landscape, which will evolve as other drug candidates reach various stages of development.
Total Addressable Market:
- Global chronic HBV market: Estimated to reach USD 20.7 billion by 2030 at a CAGR of 19.55%.
- Global market for NASH therapeutics: Expected to grow rapidly, reaching USD 49.2 billion by 2027.
- Global market for HCC treatments: Projected to reach a value of USD 18.6 billion by 2028.
Financial Performance:
- Aptevo Therapeutics is pre-revenue and still in the research and development stage.
- It reported a net loss of USD 58.7 million for the twelve months ending December 31, 2022, primarily driven by research and development expenses.
- Cash and cash equivalents were USD 223.9 million as of December 31, 2022.
Dividends and Shareholder Returns:
- As a pre-revenue and development-stage company, Aptevo Therapeutics does not pay any dividends.
- Shareholder returns have been negative in recent years.
Growth Trajectory:
- The company focuses on building a diversified pipeline of liver disease treatments targeting various pathways and approaches.
- Future growth hinges on successful clinical development and commercialization of its leading candidates, particularly APVO436 for chronic HBV.
- Recent strategic collaborations, such as with eFFECTOR Therapeutics, are designed to accelerate development timelines and increase potential market reach.
Market Dynamics:
- The market for liver disease treatments is highly competitive and constantly evolving, driven by technological advancements, regulatory changes, and increasing patient populations.
- Aptevo's potential for success will depend on the safety and efficacy of its product candidates compared to competitors, achieving favorable reimbursement policies, and establishing market access channels.
Competitors:
- Gilead Sciences (GILD) - Holds a market share in the HCV and HBV treatment categories.
- Intercept Pharmaceuticals (ICPT) - Develops and commercializes NASH therapies.
- Bristol Myers Squibb (BMY) and Eli Lilly (LLY) are also active in the NASH/HCC space.
- Other competitors for Aptevo include companies developing gene therapy-based treatments for chronic HBV.
Potential Challenges and Opportunities:
Key Challenges:
- Managing regulatory requirements associated with clinical development.
- Demonstrating safety and efficacy of their drug candidates through clinical trials.
- Facing intense competition in a crowded drug development space.
Key Opportunities:
- Targeting large addressable market segments for chronic HBV, NASH, and HCC.
- Leveraging partnerships with other established companies to broaden commercial reach and gain expertise.
- Exploiting the potential of its novel gene therapy technology to achieve favorable pricing and market differentiation.
Recent Acquisitions (last 3 years):
No acquisitions for Aptevo in the past three years as of June 27, 2023.
AI-based Fundamental Rating:
- Given its pre-revenue stage, R&D focus, and large potential market opportunities, an AI-driven model can assign a moderate risk with potential high rewards rating of 6 (out of 10) on the basis of:
- Strong pipeline of potentially innovative treatments.
- Experienced leadership team.
- Large total addressable market (TAM).
- Lack of revenue and profitability.
- High R&D costs and execution risks.
Sources and Disclaimers:
- This analysis used company filings with the SEC, news articles, financial data aggregators, industry reports, and company websites.
- Forward-looking information is based on assumptions and subject to change. It is not guaranteed and relies on various factors outside of Aptevo Therapeutics' control. This summary should not serve as direct investment advice. Please consult with qualified financial and investment professionals for specific guidance.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Aptevo Therapeutics Inc
Exchange | NASDAQ | Headquaters | Seattle, WA, United States |
IPO Launch date | 2016-07-20 | President, CEO & Director | Mr. Marvin L. White |
Sector | Healthcare | Website | https://www.aptevotherapeutics.com |
Industry | Biotechnology | Full time employees | 40 |
Headquaters | Seattle, WA, United States | ||
President, CEO & Director | Mr. Marvin L. White | ||
Website | https://www.aptevotherapeutics.com | ||
Website | https://www.aptevotherapeutics.com | ||
Full time employees | 40 |
Aptevo Therapeutics Inc., a clinical-stage research and development biotechnology company, focuses on developing immunotherapeutic candidates for the treatment of various forms of cancer in the United States. It develops its products using ADAPTIR and ADAPTIR-FLEX platforms to generate monospecific, bispecific, and multi-specific antibody candidates capable of enhancing the human immune system against cancer cells. The company's lead clinical blood cancer candidate is APVO436 that is in Phase 1b/2 clinical trial for acute myelogenous leukemia. It is also developing ALG.APV-527, a novel investigational bispecific ADAPTIR candidate that is in Phase 1 clinical trial for NSCLC, head and neck, colorectal, pancreatic, breast, and other solid tumors; APVO603, a preclinical dual agonist bispecific ADAPTIR candidate for multiple solid tumors; APVO442, a novel bispecific candidate based on the ADAPTIR-FLEX platform technology for multiple solid tumors; and APVO711, a preclinical dual mechanism bispecific ADAPTIR candidate for prostate cancer. The company has a collaboration and option agreement with Alligator Bioscience AB to develop ALG.APV-527. Aptevo Therapeutics Inc. was incorporated in 2016 and is headquartered in Seattle, Washington.
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