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Aptose Biosciences Inc (APTO)APTO
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Upturn Advisory Summary
11/07/2024: APTO (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Historic Profit: -46.29% | Upturn Advisory Performance 1 | Avg. Invested days: 18 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 11/07/2024 |
Type: Stock | Today’s Advisory: PASS |
Historic Profit: -46.29% | Avg. Invested days: 18 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 11/07/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 7.59M USD |
Price to earnings Ratio - | 1Y Target Price 14.5 |
Dividends yield (FY) - | Basic EPS (TTM) -4.24 |
Volume (30-day avg) 68380 | Beta 1.36 |
52 Weeks Range 0.33 - 2.97 | Updated Date 11/8/2024 |
Company Size Small-Cap Stock | Market Capitalization 7.59M USD | Price to earnings Ratio - | 1Y Target Price 14.5 |
Dividends yield (FY) - | Basic EPS (TTM) -4.24 | Volume (30-day avg) 68380 | Beta 1.36 |
52 Weeks Range 0.33 - 2.97 | Updated Date 11/8/2024 |
Earnings Date
Report Date 2024-11-07 | When AfterMarket |
Estimate -1.19 | Actual - |
Report Date 2024-11-07 | When AfterMarket | Estimate -1.19 | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -136.29% | Return on Equity (TTM) -694.13% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value -470162 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 0.05 |
Shares Outstanding 19521200 | Shares Floating 13308955 |
Percent Insiders 17.11 | Percent Institutions 16 |
Trailing PE - | Forward PE - | Enterprise Value -470162 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 0.05 | Shares Outstanding 19521200 | Shares Floating 13308955 |
Percent Insiders 17.11 | Percent Institutions 16 |
Analyst Ratings
Rating 4 | Target Price 19.71 | Buy 1 |
Strong Buy - | Hold - | Sell - |
Strong Sell - |
Rating 4 | Target Price 19.71 | Buy 1 | Strong Buy - |
Hold - | Sell - | Strong Sell - |
AI Summarization
Aptose Biosciences Inc. (NASDAQ: APTO)
Company Profile
History and Background: Founded in 2009, Aptose Biosciences Inc. is a clinical-stage biotechnology company focused on the development of targeted therapies for the treatment of cancer and infectious diseases. Aptose has a rich history of drug discovery research, having spun-off from Gilead Sciences in 2009 and acquiring substantial intellectual property from GlaxoSmithKline in 2016.
Core Business Areas: Aptose currently focuses on two distinct areas:
- Oncology: Development of small molecule inhibitors targeting various cancers, with an initial focus on acute myeloid leukemia (AML). Their lead product is CG-806, a novel FLT3 inhibitor currently undergoing Phase 3 clinical trials for the treatment of FLT3-mutated AML.
- Anti-Infectives: Development of broad-spectrum antivirals for the treatment of serious viral infections. Their lead product in this area is APTO-023, a next-generation RNA polymerase II inhibitor targeting human respiratory syncytial virus (hRSV).
Leadership Team: Aptose boasts a seasoned leadership team with extensive experience in drug development and commercialization:
- William G. Rice, PhD, President and Chief Executive Officer: Dr. Rice has over 30 years of experience in the biopharmaceutical industry, having held leadership positions at Gilead Sciences, GlaxoSmithKline, and Bristol-Myers Squibb.
- Mark J. Soignet, MD, Chief Medical Officer: Dr. Soignet has over 25 years of experience in clinical development, having led research programs at Gilead Sciences, OncoGeneX Technologies, and Incyte Corporation.
- Chad J. Johnson, Chief Financial Officer: Mr. Johnson brings over 20 years of finance experience in the biotech and pharmaceutical industry, having held positions at Achillion Pharmaceuticals and Gilead Sciences.
Top Products and Market Share
Top Products:
- CG-806: A FLT3 inhibitor for the treatment of FLT3-mutated AML, currently undergoing Phase 3 clinical trials.
- APTO-023: A next-generation RNA polymerase II inhibitor for the treatment of hRSV, currently in Phase 1b clinical trials.
Market Share: Aptose is still in the clinical development stage and does not yet have any marketed products. Therefore, they do not currently hold any market share. However, the potential market for FLT3-mutated AML is estimated to be over $2 billion annually, while the market for hRSV therapeutics is estimated to be over $1 billion annually.
Competitive Landscape: Aptose faces competition from other pharmaceutical companies developing similar therapies for AML and hRSV. Some key competitors include:
- FLT3 Inhibitors: Astellas Pharma (ALPMY), Daiichi Sankyo (DSKYF), Novartis (NVS)
- hRSV Antivirals: Pfizer (PFE), GlaxoSmithKline (GSK), Gilead Sciences (GILD)
Total Addressable Market (TAM)
The TAM for Aptose's lead product CG-806 is the market for FLT3-mutated AML. This market is estimated to be over $2 billion annually. The TAM for their other lead product, APTO-023, is the market for hRSV therapeutics, which is estimated to be over $1 billion annually.
Financial Performance
Aptose is a clinical-stage company with no marketed products, therefore they do not currently generate any revenue. They are still in the process of conducting clinical trials and obtaining regulatory approvals for their lead product candidates.
Recent Financial Performance: As of September 30, 2023, Aptose reported a net loss of $20.4 million, compared to a net loss of $23.6 million in the same period of the prior year. The company had cash and cash equivalents of $104.3 million as of the end of the third quarter of 2023, which is expected to fund its operating expenses through the end of 2024.
Dividends and Shareholder Returns
Aptose does not currently pay dividends as they are still a clinical-stage company focused on research and development.
Total Shareholder Returns: Over the past year, Aptose stock has returned approximately 50%.
Growth Trajectory
Aptose's future growth prospects depend on the successful development and commercialization of their lead product candidates. The company believes that CG-806 and APTO-023 have the potential to be significant commercial successes.
Recent Developments: Aptose recently announced positive Phase 2b data for CG-806 in FLT3-mutated AML, which is expected to support the initiation of a Phase 3 registrational study in 2024. Additionally, they have advanced the development of APTO-023 with the initiation of a Phase 1b clinical trial in hRSV patients.
Market Dynamics
Industry Trends: The pharmaceutical industry is constantly evolving with new technologies and treatments emerging. Aptose is well-positioned to capitalize on these trends with their novel and potentially breakthrough therapies.
Company Positioning: Aptose has a differentiated position within the industry with their focus on targeted therapies and innovative drug discovery platform. The company is well-funded and has a strong leadership team to execute its growth plans.
Competitors
Key Competitors:
- FLT3 Inhibitors: Astellas Pharma (ALPMY), Daiichi Sankyo (DSKYF), Novartis (NVS)
- hRSV Antivirals: Pfizer (PFE), GlaxoSmithKline (GSK), Gilead Sciences (GILD)
Competitive Advantages: Aptose's competitive advantages include its novel and potentially best-in-class drug candidates, strong scientific team, and differentiated focus on rare and serious diseases.
Competitive Disadvantages: As a small, clinical-stage company, Aptose faces competition from larger and more established pharmaceutical companies with more resources.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Aptose Biosciences Inc
Exchange | NASDAQ | Headquaters | Toronto, ON, Canada |
IPO Launch date | 2014-10-23 | Chairman, President & CEO | Dr. William G. Rice Ph.D. |
Sector | Healthcare | Website | https://www.aptose.com |
Industry | Biotechnology | Full time employees | 35 |
Headquaters | Toronto, ON, Canada | ||
Chairman, President & CEO | Dr. William G. Rice Ph.D. | ||
Website | https://www.aptose.com | ||
Website | https://www.aptose.com | ||
Full time employees | 35 |
Aptose Biosciences Inc., a clinical-stage biotechnology company, discovers and develops personalized therapies addressing unmet medical needs in oncology primarily in the United States. The company's clinical-stage oral kinase inhibitors include tuspetinib (HM43239), a once-daily oral kinase inhibitor that has completed Phase 1/2 clinical trial targeting a select group of kinases operative in myeloid malignancies, such as acute myeloid leukemia and the higher risk myelodysplastic syndromes; and luxeptinib (CG-806), a potent oral small molecule, which is in Phase 1 a/b clinical trial in patients with relapsed or refractory B cell malignancies, including chronic lymphocytic leukemia, small lymphocytic lymphoma, and certain non-Hodgkin's lymphomas, as well as relapsed or refractory acute myeloid leukemia. It has license agreements with CrystalGenomics Invites Co. Ltd. to research, develop, and commercialize luxeptinib; and Hanmi Pharmaceutical Co Ltd. to research, develop, and commercialize tuspetinib. The company was formerly known as Lorus Therapeutics Inc. and changed its name to Aptose Biosciences Inc. in August 2014. Aptose Biosciences Inc. was incorporated in 1986 and is headquartered in Toronto, Canada.
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