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Aprea Therapeutics Inc (APRE)APRE
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Upturn Advisory Summary
09/18/2024: APRE (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -47.7% | Upturn Advisory Performance 2 | Avg. Invested days: 35 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -47.7% | Avg. Invested days: 35 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 16.35M USD |
Price to earnings Ratio - | 1Y Target Price 15.67 |
Dividends yield (FY) - | Basic EPS (TTM) -3.01 |
Volume (30-day avg) 8027 | Beta 1.92 |
52 Weeks Range 2.86 - 8.85 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 16.35M USD | Price to earnings Ratio - | 1Y Target Price 15.67 |
Dividends yield (FY) - | Basic EPS (TTM) -3.01 | Volume (30-day avg) 8027 | Beta 1.92 |
52 Weeks Range 2.86 - 8.85 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -685.03% |
Management Effectiveness
Return on Assets (TTM) -30.26% | Return on Equity (TTM) -50.11% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value -12436619 | Price to Sales(TTM) 12.82 |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 0.35 |
Shares Outstanding 5431900 | Shares Floating 4015806 |
Percent Insiders 11.27 | Percent Institutions 44.35 |
Trailing PE - | Forward PE - | Enterprise Value -12436619 | Price to Sales(TTM) 12.82 |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 0.35 | Shares Outstanding 5431900 | Shares Floating 4015806 |
Percent Insiders 11.27 | Percent Institutions 44.35 |
Analyst Ratings
Rating 4.33 | Target Price 15 | Buy 2 |
Strong Buy 1 | Hold - | Sell - |
Strong Sell - |
Rating 4.33 | Target Price 15 | Buy 2 | Strong Buy 1 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Aprea Therapeutics Inc.: A Comprehensive Overview
Company Profile:
History and Background: Aprea Therapeutics Inc. is a clinical-stage pharmaceutical company founded in 2015 and headquartered in Princeton, New Jersey. The company focuses on developing novel therapies for the treatment of severe and chronic inflammatory diseases. Aprea leverages its proprietary BEAT technology platform to engineer and modify the immune response through its lead product candidate, APR-246.
Core Business Areas:
- Development of novel immunomodulatory therapies
- Targeting severe and chronic inflammatory diseases
- Utilizing BEAT technology for immune response modification
Leadership and Structure:
- CEO and President: Dr. Jim Miers
- Chief Medical Officer: Dr. Arlene J. Horwitz
- Chief Scientific Officer: Dr. David J. Kirn
- Board of Directors comprises experienced professionals from various backgrounds in pharma, biotechnology, and finance.
Top Products and Market Share:
Top Product:
- APR-246: A tumor necrosis factor (TNF) mimetic currently in Phase 2a clinical trials for the treatment of Crohn's disease and ulcerative colitis.
Market Share:
- TNF mimetics market is estimated to reach $20 billion by 2025.
- APR-246 is not yet commercially available, hence no definitive market share data is available.
Product Performance and Competition:
- APR-246 has demonstrated promising results in early clinical trials, showing efficacy and safety in inducing clinical remission in patients with inflammatory bowel disease.
- Competitors in the TNF mimetics market include Humira (AbbVie), Remicade (Janssen), and Enbrel (Amgen).
- APR-246 aims to differentiate itself through targeted delivery and potentially improved efficacy and safety profile.
Total Addressable Market:
- The global market for inflammatory bowel disease is expected to reach $21.7 billion by 2027.
- The US market for Crohn's disease and ulcerative colitis is estimated at $6 billion.
Financial Performance:
Recent Financials:
- As of September 30, 2023, the company had $94.8 million in cash and cash equivalents.
- Net loss for the nine months ended September 30, 2023 was $35.2 million.
- No revenue generated yet as the company is still in clinical development stage.
Financial Health:
- Strong cash position to support ongoing clinical development.
- Operating expenses primarily driven by R&D activities.
Dividends and Shareholder Returns:
- As a development-stage company, Aprea does not currently pay dividends.
- Shareholder returns have been negative in recent years due to the company's early-stage status and lack of product revenue.
Growth Trajectory:
Historical Growth:
- Rapid growth in R&D spending and clinical trial advancements.
- Significant increase in cash position through financing activities.
Future Growth:
- Continued clinical development of APR-246 and potential expansion into other indications.
- Entry into the commercial market upon regulatory approval, driving revenue growth.
- Strategic partnerships and collaborations to enhance development and commercialization efforts.
Market Dynamics:
Industry Trends:
- Growing demand for novel therapies with improved efficacy and safety profiles.
- Increasing focus on targeted therapies for personalized medicine approaches.
- Technological advancements in drug development and delivery systems.
Market Position and Adaptability:
- Aprea is well-positioned to capitalize on these trends with its innovative BEAT technology and targeted product candidates.
- The company's leadership team possesses extensive expertise and experience in developing and commercializing successful therapies.
Competitors:
Key Competitors:
- AbbVie (ABBV)
- Janssen Global Services, LLC (JNJ)
- Amgen Inc. (AMGN)
- Pfizer Inc. (PFE)
- Johnson & Johnson (JNJ)
Market Share:
- Aprea is a small company with no current market share.
- Competitors listed above hold significant market shares within the TNF mimetics market.
Competitive Advantages:
- Proprietary BEAT technology for targeted immune modulation.
- Potential for improved efficacy and safety profile compared to existing TNF mimetics.
- Experienced leadership team with a proven track record of success in drug development.
Potential Challenges and Opportunities:
Key Challenges:
- Competition from established players in the TNF mimetics market.
- Successful completion of ongoing clinical trials and regulatory approval.
- Achieving commercial success and market penetration upon product launch.
Key Opportunities:
- Expanding clinical development pipeline to target additional indications.
- Entering into strategic partnerships for commercialization and market access.
- Leveraging technological advancements to enhance product development and competitive edge.
Recent Acquisitions (last 3 years):
- Aprea has not made any acquisitions within the last three years.
AI-Based Fundamental Rating:
Rating: 7/10
Justification: Aprea demonstrates strong potential with its innovative technology and promising product candidate. The company's experienced leadership team and positive financial outlook further support its growth prospects. However, significant challenges and competition remain in the market. Overall, the AI-based analysis suggests a potentially rewarding investment opportunity with moderate risk.
Sources:
- Aprea Therapeutics Inc. Investor Relations website
- SEC filings
- Market research reports
- Industry news articles
Disclaimer:
This information is for educational purposes only and should not be construed as financial advice. It is essential to conduct thorough research and consult with financial professionals before making investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Aprea Therapeutics Inc
Exchange | NASDAQ | Headquaters | Doylestown, PA, United States |
IPO Launch date | 2019-10-03 | Co-Founder, CEO, President & Director | Dr. Oren Gilad Ph.D. |
Sector | Healthcare | Website | https://www.aprea.com |
Industry | Biotechnology | Full time employees | 7 |
Headquaters | Doylestown, PA, United States | ||
Co-Founder, CEO, President & Director | Dr. Oren Gilad Ph.D. | ||
Website | https://www.aprea.com | ||
Website | https://www.aprea.com | ||
Full time employees | 7 |
Aprea Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing and commercializing novel synthetic lethality-based cancer therapeutics that targets DNA damage response pathways. Its lead product candidate is the ATRN-119 that is in Phase I clinical trials for treating advanced solid tumors. The company is also developing ATRN-1051 for the treatment of ovarian cancer; and APRE-DDRi for the treatment of advanced solid tumors. The company is headquartered in Doylestown, Pennsylvania.
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