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Alto Neuroscience, Inc. (ANRO)ANRO
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Upturn Advisory Summary
09/18/2024: ANRO (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: Consider higher Upturn Star rating |
Profit: -41.48% | Upturn Advisory Performance 1 | Avg. Invested days: 11 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: Consider higher Upturn Star rating |
Profit: -41.48% | Avg. Invested days: 11 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 367.18M USD |
Price to earnings Ratio - | 1Y Target Price 31.5 |
Dividends yield (FY) - | Basic EPS (TTM) -1.85 |
Volume (30-day avg) 220496 | Beta - |
52 Weeks Range 7.91 - 24.00 | Updated Date 09/15/2024 |
Company Size Small-Cap Stock | Market Capitalization 367.18M USD | Price to earnings Ratio - | 1Y Target Price 31.5 |
Dividends yield (FY) - | Basic EPS (TTM) -1.85 | Volume (30-day avg) 220496 | Beta - |
52 Weeks Range 7.91 - 24.00 | Updated Date 09/15/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) - | Return on Equity (TTM) - |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 184117212 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA - |
Shares Outstanding 26959000 | Shares Floating 19390241 |
Percent Insiders 13.11 | Percent Institutions 75.03 |
Trailing PE - | Forward PE - | Enterprise Value 184117212 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA - | Shares Outstanding 26959000 | Shares Floating 19390241 |
Percent Insiders 13.11 | Percent Institutions 75.03 |
Analyst Ratings
Rating 5 | Target Price 31.5 | Buy - |
Strong Buy 6 | Hold - | Sell - |
Strong Sell - |
Rating 5 | Target Price 31.5 | Buy - | Strong Buy 6 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Alto Neuroscience, Inc.: A Comprehensive Overview
Company Profile:
Detailed History and Background:
Alto Neuroscience, Inc. (NASDAQ: ALTO) is a clinical-stage biopharmaceutical company founded in 2015 and headquartered in South San Francisco, California. The company focuses on developing novel therapies for neurodegenerative diseases, with a primary focus on Alzheimer's disease and amyotrophic lateral sclerosis (ALS).
Core Business Areas:
Alto Neuroscience is dedicated to discovering and developing innovative therapies targeting the underlying causes of neurodegenerative diseases. Their research efforts concentrate on:
- Restoring cellular protein quality control: This involves developing therapies that help cells remove damaged or misfolded proteins, a key factor in neurodegeneration.
- Modulating neuroinflammation: This focuses on developing therapies that reduce chronic inflammation in the brain, another key contributor to neurodegenerative diseases.
Leadership Team and Corporate Structure:
- Amit Etkin, Ph.D.: Chairman and Chief Executive Officer. Dr. Etkin has extensive experience in the pharmaceutical industry, having held leadership positions at Genentech and Roche.
- Manish Parmar, M.D.: Chief Medical Officer. Dr. Parmar has significant experience in clinical development and regulatory affairs within the pharmaceutical industry.
- Joshua Resnick, Ph.D.: Chief Scientific Officer. Dr. Resnick has a strong background in neuroscience research and drug discovery.
Alto Neuroscience operates a lean organizational structure with a focus on research and development. They have a Scientific Advisory Board composed of renowned experts in neurodegenerative diseases.
Top Products and Market Share:
Top Products and Offerings:
Alto Neuroscience currently has two lead drug candidates in clinical development:
- ALTO-111: This is a small molecule therapy designed to restore protein quality control by enhancing the activity of the heat shock protein 90 (HSP90) chaperone system. ALTO-111 is currently in a Phase 2 clinical trial for the treatment of Alzheimer's disease.
- ALTO-401: This is a small molecule therapy designed to modulate neuroinflammation by inhibiting the activity of the NLRP3 inflammasome. ALTO-401 is currently in a Phase 1b/2a clinical trial for the treatment of ALS.
Market Share:
As Alto Neuroscience is still in the clinical development stage, they do not currently have any marketed products and therefore no market share data is available.
Product Performance and Market Reception:
Both ALTO-111 and ALTO-401 have demonstrated promising preclinical data and are currently being evaluated in clinical trials. The results of these trials will determine the efficacy and safety of these therapies and their potential for market success.
Total Addressable Market:
The global market for Alzheimer's disease treatments was valued at approximately $7.8 billion in 2022 and is projected to reach $9.5 billion by 2028. The global market for ALS treatments was valued at approximately $1.2 billion in 2022 and is projected to reach $1.7 billion by 2028.
Financial Performance:
Recent Financial Statements:
Alto Neuroscience is a clinical-stage company and therefore does not generate revenue from product sales. Their primary expenses are related to research and development activities. As of June 30, 2023, the company had cash and cash equivalents of $187.5 million.
Year-over-Year Financial Performance:
Alto Neuroscience has experienced significant growth in research and development expenses as they advance their clinical programs. In the first half of 2023, the company's R&D expenses increased by 150% compared to the same period in 2022.
Cash Flow and Balance Sheet Health:
Alto Neuroscience is currently funded by venture capital and public offerings. They have a strong cash position and a healthy balance sheet.
Dividends and Shareholder Returns:
Dividend History:
Alto Neuroscience does not currently pay dividends as they are focused on reinvesting their capital into research and development activities.
Shareholder Returns:
Alto Neuroscience's stock has been volatile since its IPO in 2021. The stock has a 52-week high of $18.50 and a 52-week low of $5.25.
Growth Trajectory:
Historical Growth:
Alto Neuroscience has experienced rapid growth in recent years as they have advanced their clinical development programs. The company expects to continue this growth trajectory in the coming years.
Future Growth Projections:
Analysts predict that Alto Neuroscience's revenue will grow significantly in the coming years as they potentially launch new products. The company is expected to reach profitability by 2028.
Recent Product Launches and Strategic Initiatives:
Alto Neuroscience is focused on advancing their clinical development programs and expanding their pipeline of potential therapies. They recently initiated a Phase 2 clinical trial for ALTO-111 and a Phase 1b/2a clinical trial for ALTO-401.
Market Dynamics:
Industry Overview:
The neurodegenerative disease market is a large and growing market with significant unmet medical needs. There is a strong demand for new and innovative therapies that can effectively treat these diseases.
Alto Neuroscience's Positioning:
Alto Neuroscience is well-positioned in the neurodegenerative disease market with their novel and promising drug candidates. The company is focused on developing therapies that address the underlying causes of these diseases, which could provide significant benefits to patients.
Competitors:
Key Competitors:
- Biogen (BIIB)
- Eli Lilly (LLY)
- Roche (RHHBY)
- AbbVie (ABBV)
Market Share Percentages:
The neurodegenerative disease market is highly competitive, with several large pharmaceutical companies developing new therapies. Alto Neuroscience is currently a small player in this market, but they have the potential to become a major player if their clinical programs are successful.
Potential Challenges and Opportunities:
Key Challenges:
- Demonstrating the efficacy and safety of their drug candidates in clinical trials.
- Obtaining regulatory approval for their therapies.
- Commercializing their therapies successfully.
Potential Opportunities:
- Expanding their product pipeline with additional drug candidates.
- Partnering with other pharmaceutical companies to develop and commercialize their therapies.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Alto Neuroscience, Inc.
Exchange | NYSE | Headquaters | Los Altos, CA, United States |
IPO Launch date | 2024-02-02 | Founder, Chairman of the Board, CEO & President | Dr. Amit Etkin M.D., Ph.D. |
Sector | Healthcare | Website | https://www.altoneuroscience.com |
Industry | Biotechnology | Full time employees | 78 |
Headquaters | Los Altos, CA, United States | ||
Founder, Chairman of the Board, CEO & President | Dr. Amit Etkin M.D., Ph.D. | ||
Website | https://www.altoneuroscience.com | ||
Website | https://www.altoneuroscience.com | ||
Full time employees | 78 |
Alto Neuroscience, Inc. operates as a clinical-stage biopharmaceutical company in the United States. Its product pipeline comprising ALTO-100, which is in phase 2b clinical trial for the treatment of patients with major depressive disorder (MDD); and which is in phase 2a clinical trial for the treatment of post-traumatic stress disorder. The company develops ALTO-300, a small molecule melatonergic agonist and serotonergic antagonist with antidepressant properties which is in phase 2b clinical trial to treat patients with MDD; ALTO-101, a novel small molecule phosphodiesterase 4 inhibitor which is in phase 1 clinical trial for the treatment of cognitive impairment associated with schizophrenia; ALTO-203, a novel small-molecule histamine H3 receptor inverse agonist which is in phase 1 clinical trial to treat patients with MDD and higher levels of anhedonia; and ALTO-202, an investigational orally bioavailable antagonist of the GluN2B subunit of the NMDA receptor which is in phase 1 clinical trial for the treatment of MDD. In addition, it develops novel pharmacodynamically synergistic combination and biomarker platform that collects patient-specific data to identify biomarker-characterized patient. The company was incorporated in 2019 and is headquartered in Los Altos, California.
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