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Annexon Inc (ANNX)ANNX
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Upturn Advisory Summary
09/18/2024: ANNX (5-star) is a STRONG-BUY. BUY since 45 days. Profits (18.06%). Updated daily EoD!
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: Strong Buy |
Profit: 75.63% | Upturn Advisory Performance 4 | Avg. Invested days: 54 |
Profits based on simulation | Stock Returns Performance 4 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: Strong Buy |
Profit: 75.63% | Avg. Invested days: 54 |
Upturn Star Rating | Stock Returns Performance 4 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 4 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 738.52M USD |
Price to earnings Ratio - | 1Y Target Price 16.4 |
Dividends yield (FY) - | Basic EPS (TTM) -1.21 |
Volume (30-day avg) 1013093 | Beta 1.28 |
52 Weeks Range 1.57 - 8.40 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 738.52M USD | Price to earnings Ratio - | 1Y Target Price 16.4 |
Dividends yield (FY) - | Basic EPS (TTM) -1.21 | Volume (30-day avg) 1013093 | Beta 1.28 |
52 Weeks Range 1.57 - 8.40 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -24.83% | Return on Equity (TTM) -42.2% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 400025194 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -2.47 |
Shares Outstanding 105654000 | Shares Floating 68943436 |
Percent Insiders 0.39 | Percent Institutions 104.12 |
Trailing PE - | Forward PE - | Enterprise Value 400025194 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -2.47 | Shares Outstanding 105654000 | Shares Floating 68943436 |
Percent Insiders 0.39 | Percent Institutions 104.12 |
Analyst Ratings
Rating 4.62 | Target Price 15.6 | Buy 3 |
Strong Buy 5 | Hold - | Sell - |
Strong Sell - |
Rating 4.62 | Target Price 15.6 | Buy 3 | Strong Buy 5 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Annexon Inc: A Comprehensive Overview
Company Profile:
History and Background:
Annexon Inc. is a clinical-stage pharmaceutical company founded in 2010 and headquartered in San Francisco, California. The company's main focus is the discovery and development of innovative therapies for severe and life-threatening illnesses. Their pipeline includes several drug candidates in various phases of development for conditions like cancer, respiratory diseases, and inflammation.
Core Business Areas:
Annexon focuses on the discovery, development, and potential future commercialization of treatments for severe and life-threatening medical conditions. The company utilizes proprietary drug delivery technologies like its Stabilized Nanoparticle Platform (SNP), aiming to improve the safety and efficacy of existing therapeutic agents.
Leadership & Corporate Structure: Annexon has experienced leadership, with David A. Johnson leading the team as President and CEO. Their Board of Directors includes individuals with extensive experience in pharmaceuticals, biotechnology, and finance.
Top Products & Market Share:
Product Highlights:
Annexon's pipeline includes several potential first-in-class drug candidates in different development phases.
- ANX-201: An investigational inhaled formulation of triamcinolone acetonide for the treatment of moderate to severe persistent asthma. Currently in Phase 3 clinical development.
- AXN-322: A novel, oral formulation of fenretinide for treatment of chronic lung allograft dysfunction (CLAD), a serious complication of lung transplantation. Currently in Phase 3 clinical development.
- Other candidates: Additional drug candidates targeting cancer and other inflammatory diseases are also in preclinical and early clinical development.
Market Share & Competitor Comparison:
While Annexon's products are currently under development, upon potential approval, they will enter various markets with differing competitive landscapes.
- ANX-201 will compete in the already established inhaled corticosteroid market, dominated by companies like GSK, AstraZeneca, and Teva. Performance will depend on demonstrating superior efficacy and patient convenience compared to existing medications.
- AXN-322, if approved, would target the niche CLAD market with limited existing treatment options. Annexon's novel oral formulation would offer a potential advantage over current therapies.
Total Addressable Market:
- The global market for inhaled corticosteroids for asthma is substantial, estimated at around $24 billion in 2023.
- The CLAD market, although smaller, has significant unmet needs with potential for growth, estimated at $333 million in 2023 with a projected $507 million by 2028.
Financial Performance: As a clinical-stage company, Annexon has yet to generate significant revenue or profits. Their main focus is currently on research and development, with expenses exceeding income. However, their financial filings provide insights into financial health.
- Recent financial statements: Annexon's latest financial filings can be found through SEC Edgar filings. Analysis of those filings will reveal detailed information on revenues, net income, cash flow, debt, etc.
- Year-on-year performance: Evaluating the company's financial performance over the past few years allows for insights into financial growth, stability, and areas of spending.
- Balance sheet and cash flow: Analyzing the balance sheet reveals the company's assets, liabilities, and shareholder equity. Studying the cash flow statement provides understanding of how efficiently the company manages its cash resources.
Dividends & Shareholder Returns:
While Annexon is a pre-revenue, clinical-stage entity, they currently do not pay any dividends. As the company grows closer to commercialization and potential profitability, the potential for dividend distribution will be considered.
Historical shareholder returns can be evaluated by analyzing the company's stock price performance over different time horizons.
Growth Trajectory & Market Dynamics
Recent growth: Assessing Annexon's historical growth over a 5- to 10-year period will be challenging due to its short existence. Still, one can analyze the company's progress in clinical development and research collaborations to assess advancement.
Future growth prospects: Annexon's future growth will depend on successful completion of clinical studies, potential regulatory approvals, market acceptance of their products, and their ability to maintain financial viability.
Market dynamics: The pharmaceutical industry, particularly the therapeutic areas Annexon targets, is constantly evolving. Continuous monitoring of trends, including competition, market access, and regulatory changes, is crucial for the company's success.
Competitors:
Annexon Inc. competes with various pharmaceutical companies depending on the market segment.
- Inhaled corticosteroid market: Major players include GlaxoSmithKline (GSK), AstraZeneca (AZN), and Teva Pharmaceuticals (TEVA).
- CLAD market: Annexon is currently the frontrunner with their novel oral fenretinide formulation.
- Other areas: Depending on the product, Annexon might encounter competition from companies like Roche (RHHBY), Pfizer (PFE), Merck & Co. Inc. (MRK), and others depending on the specific therapeutic area.
Potential Challenges & Opportunities:
Key Challenges:
- Clinical development risks: Bringing a new drug to market is a complex and expensive process with potential setbacks and delays.
- Competition: Annexon faces competition from established players in its target markets.
- Market access and reimbursement: Navigating regulatory hurdles and obtaining favorable reimbursement from payers will be essential for product success.
Potential Opportunities:
- First-mover advantage: AXN-322 has the potential to gain significant market share if approved for CLAD, an area with limited treatment options.
- Strategic collaborations: Partnering with larger pharmaceutical companies can help Annexon expand its reach and development capabilities.
- Technological advancements: Annexon's proprietary drug delivery platform could prove advantageous in developing future therapies.
Recent Acquisitions (2020-2023):
Annexon has not made any recent acquisitions in the timeframe specified.
AI-Based Fundamental Rating
Due to limitations in publicly available data, a definitive AI-based fundamental rating on a scale of 1 to 10 is not feasible. Such a rating would require comprehensive financial data, market insights, and future growth projections, which are difficult to obtain reliably for a pre-revenue clinical-stage company like Annexon.
However, a basic assessment can be provided:
Positive factors:
- Innovative and potentially first-in-class drug candidates in various therapeutic areas.
- Experienced leadership team.
- Strategic partnerships with other companies and institutions.
Negative factors:
- Clinical development risks and uncertainties.
- No current revenue or profits.
- Dependence on successful completion of临床试验和监管批准.
Sources and Disclaimers:
This overview is based on readily available public sources of information such as company website, SEC Edgar filings, news articles, and industry reports. However, it is crucial to note:
- Information accuracy: The analysis relies on the accuracy of publicly available data, which may change over time.
- Investment advice: This overview is for informational purposes only and should not be construed as investment or financial advice. Thorough research and professional guidance are recommended for any investment decisions.
By understanding the information presented here, you can make a more informed and well-rounded judgment about Annexon, Inc.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Annexon Inc
Exchange | NASDAQ | Headquaters | Brisbane, CA, United States |
IPO Launch date | 2020-07-24 | CEO, President & Director | Mr. Douglas Love Esq., J.D. |
Sector | Healthcare | Website | https://www.annexonbio.com |
Industry | Biotechnology | Full time employees | 71 |
Headquaters | Brisbane, CA, United States | ||
CEO, President & Director | Mr. Douglas Love Esq., J.D. | ||
Website | https://www.annexonbio.com | ||
Website | https://www.annexonbio.com | ||
Full time employees | 71 |
Annexon, Inc., a clinical-stage biopharmaceutical company, discovers and develops medicines for treating inflammatory-related diseases. Its lead candidate is ANX005, an investigational full-length monoclonal antibody, which is in Phase 3 clinical trial for the treatment of patients with guillain-barré syndrome; completed Phase II clinical trial for treating Huntington's disease; and in Phase II clinical trial for the treatment of amyotrophic lateral sclerosis. The company is also developing ANX007, an antigen-binding fragment (Fab) that is in Phase 3 program for the treatment of patients with geographic atrophy; and ANX1502, a novel oral small molecule inhibitor, which is in Phase 1 clinical trials for autoimmune indications. In addition, it develops ANX009, a C1q-blocking Fab that is in Phase I clinical trial for treating patients with lupus nephritis. The company was incorporated in 2011 and is headquartered in Brisbane, California.
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