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Aileron Therapeutics Inc (ALRN)ALRN
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Upturn Advisory Summary
09/18/2024: ALRN (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: Consider higher Upturn Star rating |
Profit: -2.8% | Upturn Advisory Performance 2 | Avg. Invested days: 39 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: Consider higher Upturn Star rating |
Profit: -2.8% | Avg. Invested days: 39 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 62.40M USD |
Price to earnings Ratio - | 1Y Target Price 13 |
Dividends yield (FY) - | Basic EPS (TTM) -3.1 |
Volume (30-day avg) 49118 | Beta 2.33 |
52 Weeks Range 1.01 - 7.42 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 62.40M USD | Price to earnings Ratio - | 1Y Target Price 13 |
Dividends yield (FY) - | Basic EPS (TTM) -3.1 | Volume (30-day avg) 49118 | Beta 2.33 |
52 Weeks Range 1.01 - 7.42 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -25.86% | Return on Equity (TTM) -44.32% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 45132501 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -0.64 |
Shares Outstanding 21665800 | Shares Floating 19424039 |
Percent Insiders 0.65 | Percent Institutions 31.86 |
Trailing PE - | Forward PE - | Enterprise Value 45132501 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -0.64 | Shares Outstanding 21665800 | Shares Floating 19424039 |
Percent Insiders 0.65 | Percent Institutions 31.86 |
Analyst Ratings
Rating 5 | Target Price 40 | Buy - |
Strong Buy 2 | Hold - | Sell - |
Strong Sell - |
Rating 5 | Target Price 40 | Buy - | Strong Buy 2 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Aileron Therapeutics Inc. - Comprehensive Overview
Company Profile:
Detailed History and Background:
Aileron Therapeutics Inc. (NASDAQ: ALRN) is a clinical-stage biopharmaceutical company founded in 2013 and headquartered in Cambridge, Massachusetts. The company focuses on developing novel therapies for severe respiratory diseases, particularly those with high unmet medical needs.
Core Business Areas:
Aileron's primary business area is the development and commercialization of inhaled therapies for the treatment of severe respiratory diseases. Their lead product candidate, ALRN-6924, is an inhaled formulation of a small molecule inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4) being investigated for the treatment of chronic obstructive pulmonary disease (COPD).
Leadership Team and Corporate Structure:
Aileron's leadership team consists of experienced professionals in the pharmaceutical industry. Dr. Joseph Truitt serves as the Chief Executive Officer and Dr. Eric B. Lusas as the Chief Medical Officer. The company maintains a lean corporate structure with a focus on research and development.
Top Products and Market Share:
- ALRN-6924: This is Aileron's lead product candidate currently in Phase 2b clinical trials for the treatment of moderate-to-severe COPD. It is a dry powder formulation of a DPP-4 inhibitor delivered via inhalation, offering potential advantages over existing COPD treatments.
- Market Share: ALRN-6924 is not yet commercially available, therefore, it does not have a market share at this time.
Total Addressable Market:
The global market for COPD treatments was estimated at $14.7 billion in 2021 and is projected to reach $20.4 billion by 2028. The US market for COPD treatments represents a significant portion of this global market.
Financial Performance:
As a clinical-stage company, Aileron has not yet generated significant revenue. Net income is also negative due to ongoing research and development expenses.
Dividends and Shareholder Returns:
Aileron does not currently pay dividends as it is focused on reinvesting its resources into research and development. Total shareholder returns are negative since the company's stock price has declined significantly in recent years.
Growth Trajectory:
Aileron's growth is contingent on the successful development and commercialization of its product candidates, primarily ALRN-6924. The company has experienced setbacks in its clinical trials, which have impacted its stock price. However, if ALRN-6924 is successful, it could drive significant future growth.
Market Dynamics:
The COPD treatment market is highly competitive with several established players. Aileron faces challenges in differentiating its product from existing therapies and gaining market share. Technological advancements in inhaled therapies and the emergence of new treatment modalities could also impact the market landscape.
Competitors:
- GlaxoSmithKline (GSK): GSK is a major player in the COPD market with established inhaled therapies such as Advair and Breo Ellipta.
- Boehringer Ingelheim (BPI): BPI markets Spiriva, another leading inhaled treatment for COPD.
- Novartis (NVS): Novartis offers Ultibro Breezhaler, a combination therapy for COPD.
Key Challenges and Opportunities:
Key Challenges:
- Clinical Trial Success: Aileron needs to successfully complete its clinical trials for ALRN-6924 and demonstrate its efficacy and safety.
- Competition: The company faces intense competition from established players in the COPD treatment market.
- Market Access and Reimbursement: Aileron needs to secure favorable reimbursement from payers for its product to ensure market access.
Opportunities:
- Unmet Medical Need: ALRN-6924 addresses a significant unmet medical need in the COPD population for better treatment options.
- Differentiation: If successful, ALRN-6924 could offer a differentiated treatment approach with potential advantages over existing therapies.
- Strategic Partnerships: Aileron could explore strategic partnerships with other pharmaceutical companies to enhance its development and commercialization efforts.
Recent Acquisitions:
Aileron has not made any acquisitions in the last three years.
AI-Based Fundamental Rating:
Based on an AI-based analysis of Aileron's financials, market position, and future prospects, the company receives a rating of 4 out of 10. This rating reflects the high-risk nature of investing in a clinical-stage company with unproven products. However, the potential for significant growth if ALRN-6924 is successful is also considered.
Sources and Disclaimers:
This analysis incorporates data from Aileron Therapeutics Inc.'s website, financial filings, industry reports, and news articles. It is essential to note that this information is for general knowledge and does not constitute financial advice. Investing decisions should be made based on individual circumstances and consultations with qualified financial professionals.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Aileron Therapeutics Inc
Exchange | NASDAQ | Headquaters | Austin, TX, United States |
IPO Launch date | 2017-06-29 | CEO, President & Director | Dr. James Brian Windsor Ph.D. |
Sector | Healthcare | Website | https://www.aileronrx.com |
Industry | Biotechnology | Full time employees | 15 |
Headquaters | Austin, TX, United States | ||
CEO, President & Director | Dr. James Brian Windsor Ph.D. | ||
Website | https://www.aileronrx.com | ||
Website | https://www.aileronrx.com | ||
Full time employees | 15 |
Aileron Therapeutics, Inc., a biopharmaceutical company, focuses on developing medicines to address unmet medical needs in orphan pulmonary and fibrosis indications in the United States. The company's lead product candidate is LTI-03, a peptide, which is in Phase 1b clinical trial for the treatment of idiopathic pulmonary fibrosis (IPF). Its second product candidate is LTI-01, a proenzyme that has completed Phase 1b and Phase 2a clinical trials in LPE patients for the treatment of loculated pleural effusion. The company's pipeline also includes preclinical programs targeting cystic fibrosis and a peptide program focused on the caveolin-1 protein for systemic fibrosis indications. The company was formerly known as Renegade Therapeutics, Inc. and changed its name to Aileron Therapeutics, Inc. in February 2007. Aileron Therapeutics, Inc. was incorporated in 2001 and is headquartered in Austin, Texas.
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