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Allogene Therapeutics Inc (ALLO)ALLO
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Upturn Advisory Summary
08/23/2024: ALLO (2-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: 7.82% | Upturn Advisory Performance 3 | Avg. Invested days: 34 |
Profits based on simulation | Stock Returns Performance 2 | Last Close 08/23/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: 7.82% | Avg. Invested days: 34 |
Upturn Star Rating | Stock Returns Performance 2 |
Profits based on simulation Last Close 08/23/2024 | Upturn Advisory Performance 3 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 602.24M USD |
Price to earnings Ratio - | 1Y Target Price 9.59 |
Dividends yield (FY) - | Basic EPS (TTM) -1.59 |
Volume (30-day avg) 2271361 | Beta 0.83 |
52 Weeks Range 2.01 - 5.78 | Updated Date 09/17/2024 |
Company Size Small-Cap Stock | Market Capitalization 602.24M USD | Price to earnings Ratio - | 1Y Target Price 9.59 |
Dividends yield (FY) - | Basic EPS (TTM) -1.59 | Volume (30-day avg) 2271361 | Beta 0.83 |
52 Weeks Range 2.01 - 5.78 | Updated Date 09/17/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -416624.6% |
Management Effectiveness
Return on Assets (TTM) -23.88% | Return on Equity (TTM) -49.11% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 244602166 | Price to Sales(TTM) 9265.27 |
Enterprise Value to Revenue 3763.11 | Enterprise Value to EBITDA -1.04 |
Shares Outstanding 209112000 | Shares Floating 152097261 |
Percent Insiders 17.48 | Percent Institutions 80.71 |
Trailing PE - | Forward PE - | Enterprise Value 244602166 | Price to Sales(TTM) 9265.27 |
Enterprise Value to Revenue 3763.11 | Enterprise Value to EBITDA -1.04 | Shares Outstanding 209112000 | Shares Floating 152097261 |
Percent Insiders 17.48 | Percent Institutions 80.71 |
Analyst Ratings
Rating 4.18 | Target Price 17.64 | Buy 4 |
Strong Buy 8 | Hold 5 | Sell - |
Strong Sell - |
Rating 4.18 | Target Price 17.64 | Buy 4 | Strong Buy 8 |
Hold 5 | Sell - | Strong Sell - |
AI Summarization
Allogene Therapeutics Inc.: A Comprehensive Overview
Company Profile:
History and Background: Allogene Therapeutics, Inc. (NASDAQ: ALLO) is a clinical-stage biotechnology company pioneering the development of next-generation, off-the-shelf, allogeneic chimeric antigen receptor (CAR) T-cell therapy. Founded in 2018, Allogene leverages its proprietary cell engineering technologies to create CAR T-cell therapies with the potential to be more effective, affordable, and accessible to patients.
Core Business Areas: Allogene focuses on developing and commercializing allogeneic CAR T-cell therapies for the treatment of various cancers and hematologic malignancies. Their product pipeline comprises several CAR T candidates, including ALLO-501, ALLO-715, ALLO-316, and ALLO-647.
Leadership and Structure: The company is led by CEO David Chang, M.D., Ph.D., a seasoned leader with extensive experience in the biopharmaceutical industry. Allogene’s team comprises distinguished scientists, engineers, and industry veterans with expertise in cell therapy, oncology, and drug development.
Top Products and Market Share:
Top Products: Allogene's lead product candidate is ALLO-501, a CD19 CAR T-cell therapy for B-cell malignancies. Other notable candidates include ALLO-715 (BCMA CAR T-cell therapy) targeting multiple myeloma, and ALLO-316 (EGFR CAR T-cell therapy) for solid tumors.
Market Share: The CAR T-cell therapy market is still in its early stages of development. However, it is expected to grow significantly in the coming years. As of October 27, 2023, the global CAR T-cell therapy market size was estimated at USD 7.9 billion and is projected to reach USD 26.9 billion by 2030. In the US alone, the CAR T-cell therapy market reached USD 2.5 billion in 2022 and is anticipated to register a CAGR of 21.6% between 2023 and 2030.
Comparison to Competitors: Allogene competes with leading CAR T-cell therapy developers like Novartis, Gilead, and Bristol Myers Squibb. Although Allogene's products are not yet on the market, its novel cell engineering technologies and potentially lower manufacturing costs could offer a competitive advantage.
Total Addressable Market:
The global market for CAR T-cell therapy is expected to reach USD 26.9 billion by 2030, with the US market accounting for a significant portion of this growth. This substantial market potential reflects the increasing demand for targeted cancer therapies with improved efficacy and safety profiles.
Financial Performance:
Recent Financials: As of June 30, 2023, Allogene reported a net loss of USD 111.4 million, compared to a net loss of USD 78.4 million during the same period in 2022. The company's research and development expenses increased significantly, primarily due to the advancement of its clinical trials.
Year-over-Year Performance: Allogene's revenue has steadily grown in recent years, mainly driven by collaboration agreements and license fees. However, the company remains in the clinical development stage and is yet to generate commercial revenue from product sales.
Cash Flow and Balance Sheet: Allogene has a strong cash position with USD 705.6 million in cash and cash equivalents as of June 30, 2023.
Dividends and Shareholder Returns:
Dividends: Allogene is a clinical-stage company and does not currently pay dividends.
Shareholder Returns: Allogene's stock price has been volatile due to ongoing clinical trial results and competitive landscape dynamics.
Growth Trajectory:
Historical Growth: Over the past five years, Allogene has experienced rapid growth in its research and development activities, driven by its promising pipeline of CAR T-cell therapies.
Future Growth: Allogene anticipates continued growth through clinical development advancements, potential regulatory approvals, and commercialization of its CAR T-cell therapies. The company's strategic partnerships and collaborations with leading pharmaceutical companies are likely to further accelerate its growth trajectory.
Market Dynamics:
Industry Trends: The CAR T-cell therapy industry is characterized by rapid innovation, increasing clinical trial activity, and growing adoption by healthcare providers. Technological advancements in cell engineering and manufacturing are expected to further drive market growth.
Allogene's Position: Allogene is well-positioned in this dynamic market with its differentiated CAR T-cell therapies and strategic partnerships. The company's focus on off-the-shelf, allogeneic therapies could offer significant advantages in terms of accessibility and cost-effectiveness.
Competitors:
Key Competitors: Major competitors in the CAR T-cell therapy market include:
- Novartis (NVS)
- Gilead Sciences (GILD)
- Bristol Myers Squibb (BMY)
- Kite Pharma (KITE)
- Juno Therapeutics (JUNO)
Competitive Advantages and Disadvantages: Allogene's potential competitive advantages include its proprietary cell engineering technologies, which could lead to more effective and affordable CAR T-cell therapies. However, it faces challenges in terms of successfully navigating clinical trials, obtaining regulatory approvals, and establishing its brand in a competitive market.
Potential
Challenges: Allogene faces several challenges, including the complexity of CAR T-cell therapy development, the competitive landscape, and the regulatory approval process.
Opportunities: Opportunities include the significant unmet need for effective cancer treatments, the growing market for CAR T-cell therapy, and the potential for strategic partnerships.
Recent Acquisitions:
Allogene has not made any acquisitions in the last three years.
AI-Based Fundamental Rating:
Based on an AI-based analysis of Allogene's fundamentals, we assign the company a rating of 7 out of 10. This rating considers factors such as the company's strong financial position, promising product pipeline, and experienced leadership team. However, the company's clinical-stage status and uncertain regulatory environment introduce some risk.
Disclaimer:
This information is provided for educational purposes only and should not be considered financial advice. Please consult with a qualified financial advisor before making any investment decisions.
Sources:
- Allogene Therapeutics, Inc. website (https://allogene.com/)
- Securities and Exchange Commission (SEC) filings (https://www.sec.gov/edgar/search/)
- EvaluatePharma (https://www.evaluate.com/)
- ClinicalTrials.gov (https://clinicaltrials.gov/)
- Reuters (https://www.reuters.com/)
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Allogene Therapeutics Inc
Exchange | NASDAQ | Headquaters | South San Francisco, CA, United States |
IPO Launch date | 2018-10-11 | Co-Founder, President, CEO & Director | Dr. David D. Chang M.D., Ph.D. |
Sector | Healthcare | Website | https://www.allogene.com |
Industry | Biotechnology | Full time employees | 232 |
Headquaters | South San Francisco, CA, United States | ||
Co-Founder, President, CEO & Director | Dr. David D. Chang M.D., Ph.D. | ||
Website | https://www.allogene.com | ||
Website | https://www.allogene.com | ||
Full time employees | 232 |
Allogene Therapeutics, Inc., a clinical stage immuno-oncology company, develops and commercializes genetically engineered allogeneic T cell therapies for the treatment of cancer. It develops, manufactures, and commercializes UCART19, an allogeneic chimeric antigen receptor (CAR) T cell product candidate for the treatment of pediatric and adult patients with R/R CD19 positive B-cell acute lymphoblastic leukemia (ALL). The company also develops cemacabtagene ansegedleucel, an engineered allogeneic CAR T cell product candidate that targets CD19 for the treatment of large B-cell lymphoma; and is in Phase 1b clinical trial for the treatment of chronic lymphocytic leukemia. In addition, it is developing ALLO-715, an allogeneic CAR T cell product candidate that is in a Phase 1 clinical trial for treating R/R multiple myeloma; ALLO-605, an allogeneic CAR T cell product candidate that is in a Phase I clinical trial for the treatment of multiple myeloma; ALLO-647, an anti-CD52 monoclonal antibody; CD70 to treat renal cell cancer; ALLO-316, an allogeneic CAR T cell product candidate that is in Phase 1 clinical trial for the treatment of advanced or metastatic RCC; ALLO-329 for the treatment of certain autoimmune diseases; DLL3 for the treatment of small cell lung cancer and other aggressive neuroendocrine tumors; and Claudin 18.2 for the treatment of gastric and pancreatic cancer. The company has license and collaboration agreements with Pfizer Inc.; Servier; Cellectis S.A.; and Notch Therapeutics Inc. It also has a strategic collaboration agreement with The University of Texas MD Anderson Cancer Center for the preclinical and clinical investigation of allogeneic CAR T cell product candidates; and a strategic partnership with Foresight Diagnostics to develop MRD-based In-Vitro Diagnostic for use in ALPHA3. The company was incorporated in 2017 and is headquartered in South San Francisco, California.
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