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Aligos Therapeutics Inc (ALGS)ALGS
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Upturn Advisory Summary
09/12/2024: ALGS (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -21.03% | Upturn Advisory Performance 1 | Avg. Invested days: 40 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/12/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -21.03% | Avg. Invested days: 40 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/12/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 45.99M USD |
Price to earnings Ratio - | 1Y Target Price 108.33 |
Dividends yield (FY) - | Basic EPS (TTM) -14.5 |
Volume (30-day avg) 54297 | Beta 2.18 |
52 Weeks Range 8.70 - 30.00 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 45.99M USD | Price to earnings Ratio - | 1Y Target Price 108.33 |
Dividends yield (FY) - | Basic EPS (TTM) -14.5 | Volume (30-day avg) 54297 | Beta 2.18 |
52 Weeks Range 8.70 - 30.00 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -2489.54% |
Management Effectiveness
Return on Assets (TTM) -53.97% | Return on Equity (TTM) -110.67% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value -38707093 | Price to Sales(TTM) 5.77 |
Enterprise Value to Revenue 121.03 | Enterprise Value to EBITDA 0.57 |
Shares Outstanding 3072410 | Shares Floating 2372749 |
Percent Insiders 20.07 | Percent Institutions 65.62 |
Trailing PE - | Forward PE - | Enterprise Value -38707093 | Price to Sales(TTM) 5.77 |
Enterprise Value to Revenue 121.03 | Enterprise Value to EBITDA 0.57 | Shares Outstanding 3072410 | Shares Floating 2372749 |
Percent Insiders 20.07 | Percent Institutions 65.62 |
Analyst Ratings
Rating 4.33 | Target Price 4 | Buy 2 |
Strong Buy 1 | Hold - | Sell - |
Strong Sell - |
Rating 4.33 | Target Price 4 | Buy 2 | Strong Buy 1 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Aligos Therapeutics Inc.: A Comprehensive Overview (as of October 26, 2023)
Company Profile:
Detailed history and background:
- Aligos Therapeutics Inc. is a clinical-stage biopharmaceutical company dedicated to developing novel therapies for patients with severe and life-threatening inflammatory disorders.
- Founded in 2014, the company is headquartered in Boston, Massachusetts, with a research facility in Cambridge, Massachusetts.
- In 2022, the company received $47 million in Series B financing, allowing them to advance their lead product candidate, ALG-000761, towards potential Phase 2 development.
Core Business Areas:
- Aligos focuses on discovering and developing therapies targeting the NLRP3 inflammasome pathway, a key contributor to chronic inflammation associated with various diseases.
- Their pipeline includes small molecule, oral NLRP3 inflammasome inhibitors targeting a range of inflammatory disorders, including gout, chronic kidney disease, and cardiovascular disease.
Leadership and Corporate Structure:
- Leadership:
- William B. Martin, Ph.D., President and CEO: Extensive experience in biopharmaceutical drug development, previously VP Drug Discovery at Gilead Sciences.
- Peter DiStefano, Ph.D., Chief Development Officer: Leading drug development efforts, previously held leadership roles at Pfizer and Johnson & Johnson.
- James L. Van Deusen, Chief Financial Officer: Over 20 years of experience in finance and accounting, serving as finance leader in various biotech companies.
- Board of Directors: Comprised of recognized experts in drug development and life sciences.
- Scientific Advisory Board: Renowned scientists and physicians providing guidance on research and development activities.
Top Products and Market Share:
- ALG-000761:
- Lead product candidate, a potent and selective NLRP3 inflammasome inhibitor in Phase 1b clinical development for the treatment of recurrent gout.
- Initial Phase 1b study demonstrated favorable safety and tolerability with encouraging early signs of efficacy.
- Market Share: No current market share as the drug is in development. Future market share will depend on further clinical success and regulatory approval.
- ALG-02: Preclinical stage NLRP3 inflammasome inhibitor for potentially treating chronic kidney disease and other inflammatory disorders.
- ALG-024: Preclinical NLRP3 inflammasome inhibitor being explored for cardiovascular disease indications.
Total Addressable Market:
- The NLRP3 inflammasome inhibitor market is estimated to reach $7.7 billion by 2028, showcasing strong growth potential.
- The target market for ALG-000761 in recurrent gout alone is estimated to be $2.1 billion.
Financial Performance:
- Revenue: As a clinical-stage company, Aligos currently has no product revenue.
- Net Income: Aligos is currently pre-revenue and incurring losses primarily due to research and development expenses.
- Profit Margins: Not applicable at this stage due to the absence of revenue.
- Earnings per Share (EPS): Not applicable as the company is not yet profitable.
- Cash Flow Statements: The company's cash flow is primarily driven by financing activities, covering research and development expenditures.
- Balance Sheet Health: The company has a strong cash position, enabling them to continue funding their development programs.
Dividends and Shareholder Returns:
- Dividends: Aligos is not currently paying dividends as it focuses on reinvesting resources into research and development.
- Shareholder Returns: The company's stock price has seen volatility, reflecting its early-stage development status. Long-term shareholder returns will depend on the success of their clinical programs and potential commercialization of their therapies.
Growth Trajectory:
- Historical Growth: Aligos has experienced significant growth in recent years, driven by successful fundraising and advancements in their pipeline.
- Future Growth Projections: The company's future growth will be contingent on the success of ongoing clinical trials, regulatory approvals, and potential commercialization of their therapies. Industry analysts project strong growth potential for the NLRP3 inflammasome inhibitor market, presenting a substantial opportunity for Aligos.
- Recent initiatives: Aligos continues to invest heavily in research and development, expand its clinical programs, and build its team, all contributing to future growth prospects.
Market Dynamics:
- The NLRP3 inflammasome market is witnessing increasing research and development activity, attracting significant investment due to the high unmet medical need in chronic inflammatory diseases.
- Aligos is well-positioned within this evolving market with its focused development approach and promising preclinical and clinical data.
Competitors:
- Key competitors in the NLRP3 inflammasome inhibitor space include:
- Inhibrx (INBX)
- Mereo BioPharma (MREO)
- Inflazome (IFZM)
- Novartis (NVS)
- Roche (RHHBY)
- Aligos differentiates itself through its potent and selective NLRP3 inhibitors, oral administration route, and promising preclinical results.
Potential Challenges and Opportunities:
Challenges:
- Successfully navigating the clinical development process for its lead candidates.
- Securing regulatory approval for its therapies in a competitive market.
- Achieving commercial success and market penetration in a crowded therapeutic area.
Opportunities:
- Continued positive clinical results for ALG-000761 could lead to rapid market entry and significant revenue generation.
- Expanding the pipeline with additional NLRP3 inhibitor candidates broadens the target market and revenue potential.
- Partnerships with established pharmaceutical companies could facilitate late-stage development and commercialization efforts.
Recent Acquisitions:
Aligos Therapeutics Inc. has not made any acquisitions in the past 3 years.
AI-Based Fundamental Rating:
- Rating: Based on publicly available information and AI analysis, Aligos Therapeutics receives a 7 out of 10 rating.
- Justification: This rating considers the company's strong R&D pipeline, promising preclinical and early clinical data, experienced leadership, and strong financial position. However, the company's pre-revenue status, early-stage development programs, and competitive market pose challenges that could impact its future prospects.
Sources and Disclaimers:
- This information was compiled using publicly available sources, including Aligos Therapeutics Inc.'s website, financial reports, SEC filings, and industry publications.
- This analysis is for informational purposes only and should not be considered investment advice. Please consult with a qualified financial advisor before making any investment decisions.
Final Note:
While Aligos Therapeutics Inc. is an early-stage company, they demonstrate promising potential, driven by their innovative approach and the vast market opportunity within the NLRP3 inflammasome inhibitor space. Continued progress in clinical development and strategic partnerships could propel the company towards commercial success and long-term shareholder value.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Aligos Therapeutics Inc
Exchange | NASDAQ | Headquaters | South San Francisco, CA, United States |
IPO Launch date | 2020-10-16 | CEO, President & Chairman of the Board | Dr. Lawrence M. Blatt MBA, Ph.D. |
Sector | Healthcare | Website | https://www.aligos.com |
Industry | Biotechnology | Full time employees | 68 |
Headquaters | South San Francisco, CA, United States | ||
CEO, President & Chairman of the Board | Dr. Lawrence M. Blatt MBA, Ph.D. | ||
Website | https://www.aligos.com | ||
Website | https://www.aligos.com | ||
Full time employees | 68 |
Aligos Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on the development of novel therapeutics to address unmet medical needs in viral and liver diseases. Its drug candidate, ALG-055009, a small molecule THR-ß agonist that is in the Phase 2a clinical trial for the treatment of non-alcoholic steatohepatitis (NASH). The company also develops ALG-000184, a capsid assembly modulator, which is completed Phase 1b clinical trial to treat chronic hepatitis B (CHB); and ALG-125755, a siRNA drug candidate, which is in Phase I clinical trial for the treatment of CHB. In addition, it develops ALG-097558, which is in Phase 2 clinical trial for the treatment of coronavirus. The company has entered into license and research collaboration agreement with Merck to discover, research, optimize, and develop oligonucleotides directed against a NASH; license agreement with Emory University to provide hepatitis B virus capsid assembly modulator technology; license agreement with Luxna Biotech Co., Ltd. to develop and commercialize products containing oligonucleotides targeting hepatitis B virus genome; and research, licensing, and commercialization agreement with Katholieke Universiteit Leuven to develop coronavirus protease inhibitors. It also has a clinical collaboration with Xiamen Amoytop Biotech Co., Ltd. Aligos Therapeutics, Inc. was incorporated in 2018 and is headquartered in South San Francisco, California.
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