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Akebia Ther (AKBA)AKBA
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Upturn Advisory Summary
09/18/2024: AKBA (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: WEAK BUY |
Profit: -57.26% | Upturn Advisory Performance 2 | Avg. Invested days: 29 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: WEAK BUY |
Profit: -57.26% | Avg. Invested days: 29 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 288.09M USD |
Price to earnings Ratio - | 1Y Target Price 5.5 |
Dividends yield (FY) - | Basic EPS (TTM) -0.21 |
Volume (30-day avg) 1735638 | Beta 0.77 |
52 Weeks Range 0.78 - 2.48 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 288.09M USD | Price to earnings Ratio - | 1Y Target Price 5.5 |
Dividends yield (FY) - | Basic EPS (TTM) -0.21 | Volume (30-day avg) 1735638 | Beta 0.77 |
52 Weeks Range 0.78 - 2.48 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin -23.18% | Operating Margin (TTM) -19.99% |
Management Effectiveness
Return on Assets (TTM) -8.84% | Return on Equity (TTM) -553.45% |
Revenue by Products
Revenue by Products - Current and Previous Year
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 304413494 | Price to Sales(TTM) 1.65 |
Enterprise Value to Revenue 1.74 | Enterprise Value to EBITDA 65.76 |
Shares Outstanding 210288000 | Shares Floating 190319242 |
Percent Insiders 2.17 | Percent Institutions 27 |
Trailing PE - | Forward PE - | Enterprise Value 304413494 | Price to Sales(TTM) 1.65 |
Enterprise Value to Revenue 1.74 | Enterprise Value to EBITDA 65.76 | Shares Outstanding 210288000 | Shares Floating 190319242 |
Percent Insiders 2.17 | Percent Institutions 27 |
Analyst Ratings
Rating 4.33 | Target Price 3.88 | Buy 2 |
Strong Buy 1 | Hold - | Sell - |
Strong Sell - |
Rating 4.33 | Target Price 3.88 | Buy 2 | Strong Buy 1 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Akebia Therapeutics (AKBA): A Comprehensive Overview
Company Profile:
Detailed history and background of Akebia Ther. Akebia Therapeutics, Inc. is a biopharmaceutical company focused on developing and commercializing innovative treatments for people with kidney disease. Founded in 2007 and headquartered in Cambridge, Massachusetts, Akebia has a long-standing commitment to making a difference in the lives of patients facing this critical health challenge.
Description of the company’s core business areas. The company's primary business areas include:
- Developing and commercializing innovative therapeutics for kidney diseases, with a focus on chronic kidney disease (CKD) and anemia related to CKD.
- Conducting clinical research and development on various drug candidates targeting different pathways involved in kidney disease progression.
- Collaborating with leading research institutions and pharmaceutical companies to advance its pipeline and bring new treatment options to patients.
Overview of the company’s leadership team and corporate structure. Akebia boasts a seasoned leadership team with extensive experience in the pharmaceutical industry. John P. Butler serves as the company's President and Chief Executive Officer, leading its strategic direction and operations. The leadership team also comprises seasoned individuals with expertise in research and development, finance, and marketing. The company operates through a Board of Directors, responsible for overseeing its governance and strategic decisions.
Top Products and Market Share:
Identification and description of Akebia Ther's top products and offerings. Akebia's current marketed product is Vadadustat (brand name Vadraw) for the treatment of anemia due to chronic kidney disease (CKD). Vadadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) that stimulates the body's natural production of erythropoietin (EPO), a hormone essential for red blood cell production. This helps address anemia in patients with CKD, a common and debilitating complication affecting their quality of life.
Analysis of the market share of these products in the global and US markets. As of November 2023, Vadadustat holds a modest market share in the CKD-associated anemia treatment market. While facing established competition from injectable EPOs and other HIF-PHIs, Vadadustat's oral administration and favorable safety profile offer potential advantages. However, broader adoption requires continued marketing efforts and clinical data demonstrating its long-term efficacy and safety.
Comparison of product performance and market reception against competitors. Compared to injectable EPOs, Vadadustat's oral formulation offers greater convenience for patients. However, it faces competition from other HIF-PHIs, such as roxadustat and daprodustat, which have similar mechanisms of action. Market reception suggests a growing acceptance of Vadadustat as a viable treatment option, but its long-term market share will depend on its ability to differentiate itself from competitors in terms of efficacy, safety, and pricing.
Total Addressable Market.
The global market for CKD-associated anemia treatment is estimated to reach USD 11.3 billion by 2028, growing at a CAGR of 7.5% from 2021 to 2028. This growth is driven by the rising prevalence of CKD globally, coupled with the increasing adoption of novel therapies like HIF-PHIs. Akebia operates within this substantial market, aiming to capture a significant share with Vadadustat and its pipeline of potential therapies.
Financial Performance:
Detailed analysis of recent financial statements, including revenue, net income, profit margins, and earnings per share (EPS). Akebia is currently in a commercialization stage, focusing on expanding Vadadustat's market reach. As of the latest financial statements (Q3 2023), the company reported revenue of USD 23.4 million, primarily from Vadadustat sales in the US. However, it continues to incur net losses due to ongoing R&D expenses and marketing investments. Profit margins remain negative, and EPS is yet to turn positive. This reflects the typical trajectory of emerging biopharma companies investing heavily in growth before achieving profitability.
Year-over-year financial performance comparison. Akebia's revenue has been steadily increasing, reflecting progressive market penetration of Vadadustat. However, the company's net loss has also widened as R&D and commercialization expenses continue to rise. Operating expenses, including marketing and administrative costs, have also increased significantly compared to the previous year. This highlights Akebia's ongoing efforts to establish its market position and expand its reach.
Examination of cash flow statements and balance sheet health. Akebia's current cash and equivalents stand at USD 247.3 million, providing sufficient runway for ongoing operations and clinical development activities. The company's balance sheet appears relatively healthy, with total assets exceeding total liabilities. However, its continued reliance on external financing and cash burn remain key factors to monitor as the company progresses towards financial sustainability.
Dividends and Shareholder Returns:
-Dividend History: Overview of Akebia Ther's dividend payout history, including recent dividend yields and payout ratios. Akebia is currently in a growth stage and does not pay dividends. The company's focus remains on reinvesting its earnings into R&D and commercialization efforts to maximize shareholder value through long-term growth.
-Shareholder Returns: Analysis of total shareholder returns over various time periods (e.g., 1 year, 5 years, 10 years). Akebia's stock price has experienced volatility since its IPO in 2014. Shareholder returns have been negative in the short term (1 year) but positive over longer time horizons (5 years, 10 years). This reflects the company's development stage, where investors anticipate future potential rather than immediate returns.
Growth Trajectory:
Historical growth analysis over the past 5 to 10 years. Akebia has demonstrated significant growth over the past 5-10 years. The company successfully transitioned from a pre-clinical stage to commercializing its lead product, Vadadustat. This progress is reflected in its increasing revenue, expanding clinical development pipeline, and growing market presence.
Future growth projections based on industry trends and company guidance. Akebia's future growth will likely be driven by several factors, including:
- Expanding Vadadustat's market share in the CKD-associated anemia treatment market
- Launching additional product candidates from its clinical pipeline
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Akebia Ther
Exchange | NASDAQ | Headquaters | Cambridge, MA, United States |
IPO Launch date | 2014-03-20 | CEO, President & Director | Mr. John P. Butler MBA |
Sector | Healthcare | Website | https://www.akebia.com |
Industry | Drug Manufacturers - Specialty & Generic | Full time employees | 167 |
Headquaters | Cambridge, MA, United States | ||
CEO, President & Director | Mr. John P. Butler MBA | ||
Website | https://www.akebia.com | ||
Website | https://www.akebia.com | ||
Full time employees | 167 |
Akebia Therapeutics, Inc., a biopharmaceutical company, focuses on the development and commercialization of therapeutics for patients with kidney diseases. The company's lead product investigational product candidate is Vafseo (vadadustat), an oral hypoxia-inducible factor prolyl hydroxylase, which is in Phase III development for the treatment of anemia due to chronic kidney disease (CKD) in dialysis-dependent and non-dialysis dependent patients. It offers Auryxia, a ferric citrate that is used to control the serum phosphorus levels in adult patients with DD-CKD on dialysis; and the treatment of iron deficiency anemia in adult patients with CKD not on dialysis. The company's product pipeline includes AKB-9090, a drug targeting critical-care indications; and AKB-10108, a drug targeting conditions related to premature birth. It has collaboration agreements with Mitsubishi Tanabe Pharma Corporation for the development and commercialization of vadadustat in Japan and other Asian countries, as well as research and license agreement with Janssen Pharmaceutica NV for the development and commercialization of hypoxia-inducible factor prolyl hydroxylase targeted compounds worldwide. Akebia Therapeutics, Inc. was incorporated in 2007 and is headquartered in Cambridge, Massachusetts.
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