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Adaptimmune Therapeutics Plc (ADAP)ADAP
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Upturn Advisory Summary
08/22/2024: ADAP (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -13.45% | Upturn Advisory Performance 2 | Avg. Invested days: 34 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 08/22/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -13.45% | Avg. Invested days: 34 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 08/22/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 268.53M USD |
Price to earnings Ratio - | 1Y Target Price 2.56 |
Dividends yield (FY) - | Basic EPS (TTM) -0.36 |
Volume (30-day avg) 2347942 | Beta 2.2 |
52 Weeks Range 0.42 - 2.05 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 268.53M USD | Price to earnings Ratio - | 1Y Target Price 2.56 |
Dividends yield (FY) - | Basic EPS (TTM) -0.36 | Volume (30-day avg) 2347942 | Beta 2.2 |
52 Weeks Range 0.42 - 2.05 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin -51.25% | Operating Margin (TTM) 53.58% |
Management Effectiveness
Return on Assets (TTM) -15.84% | Return on Equity (TTM) -65.04% |
Revenue by Products
Revenue by Products - Current and Previous Year
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 101091717 | Price to Sales(TTM) 1.9 |
Enterprise Value to Revenue 0.71 | Enterprise Value to EBITDA -1.71 |
Shares Outstanding 255744992 | Shares Floating 1023293789 |
Percent Insiders 0.38 | Percent Institutions 61.85 |
Trailing PE - | Forward PE - | Enterprise Value 101091717 | Price to Sales(TTM) 1.9 |
Enterprise Value to Revenue 0.71 | Enterprise Value to EBITDA -1.71 | Shares Outstanding 255744992 | Shares Floating 1023293789 |
Percent Insiders 0.38 | Percent Institutions 61.85 |
Analyst Ratings
Rating 4 | Target Price 5.58 | Buy 2 |
Strong Buy 4 | Hold 2 | Sell 1 |
Strong Sell - |
Rating 4 | Target Price 5.58 | Buy 2 | Strong Buy 4 |
Hold 2 | Sell 1 | Strong Sell - |
AI Summarization
Adaptimmune Therapeutics Plc: A Comprehensive Overview
Company Profile:
History and Background:
Adaptimmune Therapeutics Plc (ADAP) is a clinical-stage biopharmaceutical company focused on the development of novel T-cell therapies for cancer and other serious diseases. Founded in 2008, the company's headquarters are located in Oxfordshire, UK, with additional offices in the US and France.
Adaptimmune is a pioneer in the field of T-cell therapy, leveraging its proprietary SPEAR (Specific Peptide Enhanced Affinity Receptor) technology platform to engineer T-cells that specifically target and destroy tumor cells.
Core Business Areas:
Adaptimmune's core business areas include:
- Developing and commercializing novel T-cell therapies for cancer, focusing on hematological malignancies and solid tumors.
- Research and development of T-cell therapies for other serious diseases, including autoimmune disorders and infectious diseases.
- Licensing its SPEAR technology platform to other pharmaceutical companies.
Leadership Team and Corporate Structure:
- James Noble, Ph.D.: Chief Executive Officer
- Ulrich Keilholz, M.D.: Chief Medical Officer
- John Lunghofer: Chief Financial Officer
- Gwyn Beattie: Chief Scientific Officer
Adaptimmune has a global presence, with operations in the United States, Europe, and Asia. The company's board of directors includes experienced individuals with expertise in pharmaceuticals, finance, and academia.
Top Products and Market Share:
Top Products:
- afamitresgene autoleucel (afami-cel): A T-cell therapy currently in Phase 3 clinical trials for the treatment of synovial sarcoma.
- ADP-A2M4: A T-cell therapy in Phase 2 clinical trials for the treatment of MAGE-A4 positive solid tumors.
- ADP-A2M4CD8: A second-generation T-cell therapy in Phase 1 clinical trials for the treatment of MAGE-A4 positive solid tumors.
Market Share:
Adaptimmune's current T-cell therapies are in the development stage and have not yet reached the market. However, the company's proprietary SPEAR technology platform has the potential to address a significant unmet need in the growing T-cell therapy market.
Comparison with Competitors:
Adaptimmune's main competitors in the T-cell therapy market include:
- Novartis (NVS)
- Bristol Myers Squibb (BMY)
- Kite Pharma (KITE)
Adaptimmune's differentiated technology platform and focus on personalized therapies could potentially give it an edge over its competitors.
Total Addressable Market:
The global T-cell therapy market is estimated to be worth over $10 billion and is expected to grow at a CAGR of over 20% in the coming years. The increasing prevalence of cancer and the growing demand for personalized therapies are driving the growth of this market.
Financial Performance:
Recent Financial Statements:
- Revenue: As of September 30, 2023, Adaptimmune had no product revenue.
- Net Income: As of September 30, 2023, Adaptimmune had a net loss of $63.7 million.
- Profit Margins: Adaptimmune is a clinical-stage company and is not yet profitable.
- Earnings per Share (EPS): Adaptimmune does not currently have any earnings per share.
Financial Performance Comparison:
Adaptimmune's financial performance is typical for a clinical-stage biopharmaceutical company. The company is investing heavily in research and development, which is resulting in significant losses. However, the company is well-funded and has a strong pipeline of potential products.
Cash Flow and Balance Sheet Health:
As of September 30, 2023, Adaptimmune had cash and cash equivalents of $244.5 million. The company's balance sheet is healthy and it has sufficient cash to fund its operations for the foreseeable future.
Dividends and Shareholder Returns:
Dividend History:
Adaptimmune is a clinical-stage company and does not currently pay dividends.
Shareholder Returns:
Over the past year, Adaptimmune's stock price has increased by over 50%. However, it is important to note that this is a small-cap biotechnology company and its stock price is subject to significant volatility.
Growth Trajectory:
Historical Growth:
Over the past five years, Adaptimmune has experienced significant growth in its clinical development pipeline. The company has advanced multiple T-cell therapies into clinical trials and is on track to potentially launch its first product in the next few years.
Future Growth Projections:
Analysts expect Adaptimmune to continue to grow its revenue and market share in the coming years as its product pipeline matures. The company is well-positioned to capitalize on the growing demand for T-cell therapies.
Recent Product Launches and Strategic Initiatives:
Adaptimmune is currently focused on advancing its clinical development pipeline. The company's most important upcoming milestones include the potential approval of afami-cel for the treatment of synovial sarcoma and the initiation of Phase 3 clinical trials for ADP-A2M4.
Market Dynamics:
Industry Overview:
The T-cell therapy market is a rapidly growing and evolving industry. New technologies and therapies are being developed at a rapid pace, and the market is becoming increasingly competitive.
Adaptimmune's Position:
Adaptimmune is well-positioned within the T-cell therapy market due to its proprietary SPEAR technology platform and its focus on personalized therapies. The company has a strong pipeline of potential products and is well-funded to execute its growth strategy.
Competitors:
Adaptimmune's main competitors in the T-cell therapy market include Novartis, Bristol Myers Squibb, and Kite Pharma. These companies have a larger market share and more resources than Adaptimmune, but they also have a more mature product pipeline.
Competitive Advantages and Disadvantages:
Competitive Advantages:
- Proprietary SPEAR technology platform
- Focus on personalized therapies
- Strong clinical development pipeline
Competitive Disadvantages:
- Small-cap biotechnology company
- No approved products
- Limited resources
Potential Challenges and Opportunities:
Challenges:
- Competition from larger pharmaceutical companies
- Regulatory hurdles
- Clinical development risks
Opportunities:
- Growing T-cell therapy market
- Potential partnerships with larger pharmaceutical companies
- New product approvals
AI-Based Fundamental Rating:
Based on an AI-based fundamental rating system, Adaptimmune receives a rating of 7 out of 10. This rating is based on the company's strong financial health, promising product pipeline, and potential for market growth. However, investors should be aware of the company's clinical development risks and competitive challenges.
Sources and Disclaimers:
Primary Sources:
- Adaptimmune Therapeutics Plc website
- SEC filings
- Analyst reports
Disclaimer:
This analysis is intended for informational purposes only and should not be considered investment advice. Investing in early-stage biotechnology companies carries significant risks. Investors should conduct their own research and consult with a financial advisor before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Adaptimmune Therapeutics Plc
Exchange | NASDAQ | Headquaters | - |
IPO Launch date | 2015-05-06 | CEO, Principal Accounting Officer & Director | Mr. Adrian G. Rawcliffe |
Sector | Healthcare | Website | https://www.adaptimmune.com |
Industry | Biotechnology | Full time employees | 449 |
Headquaters | - | ||
CEO, Principal Accounting Officer & Director | Mr. Adrian G. Rawcliffe | ||
Website | https://www.adaptimmune.com | ||
Website | https://www.adaptimmune.com | ||
Full time employees | 449 |
Adaptimmune Therapeutics plc, a clinical-stage biopharmaceutical company, provides novel cell therapies primarily to cancer patients in the United States and the United Kingdom. It develops SPEARHEAD-1 that is in phase II clinical trials with ADP-A2M4 for synovial sarcoma; SURPASS-3 that is in phase II clinical trial with ADP-A2M4CD8 for people with platinum resistant ovarian cancer; and SURPASS that is in phase I clinical trials in patients with head and neck, and urothelial cancers. The company has strategic collaboration and license agreement with Genentech, Inc. and F. Hoffman-La Roche Ltd to develop personalized allogeneic and allogeneic T-cell therapies; research, collaboration, and license agreement with Universal Cells, Inc.; third-party collaborations with Noile-Immune and Alpine Immune Sciences; and strategic alliance agreement with the MD Anderson Cancer Center. Adaptimmune Therapeutics plc was founded in 2008 and is headquartered in Abingdon, the United Kingdom.
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