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Achilles Therapeutics PLC ADR (ACHL)ACHL
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Upturn Advisory Summary
09/18/2024: ACHL (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -17.7% | Upturn Advisory Performance 1 | Avg. Invested days: 62 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -17.7% | Avg. Invested days: 62 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 30.15M USD |
Price to earnings Ratio - | 1Y Target Price 2.83 |
Dividends yield (FY) - | Basic EPS (TTM) -1.59 |
Volume (30-day avg) 47901 | Beta 1.3 |
52 Weeks Range 0.63 - 1.76 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 30.15M USD | Price to earnings Ratio - | 1Y Target Price 2.83 |
Dividends yield (FY) - | Basic EPS (TTM) -1.59 | Volume (30-day avg) 47901 | Beta 1.3 |
52 Weeks Range 0.63 - 1.76 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -26.82% | Return on Equity (TTM) -44.22% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value -60413380 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 1.66 |
Shares Outstanding 41087900 | Shares Floating 24934193 |
Percent Insiders 6.51 | Percent Institutions 54.01 |
Trailing PE - | Forward PE - | Enterprise Value -60413380 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 1.66 | Shares Outstanding 41087900 | Shares Floating 24934193 |
Percent Insiders 6.51 | Percent Institutions 54.01 |
Analyst Ratings
Rating 3.5 | Target Price 8.8 | Buy 1 |
Strong Buy 1 | Hold 1 | Sell 1 |
Strong Sell - |
Rating 3.5 | Target Price 8.8 | Buy 1 | Strong Buy 1 |
Hold 1 | Sell 1 | Strong Sell - |
AI Summarization
Achilles Therapeutics PLC ADR: A Comprehensive Overview
Company Profile:
History and Background: Achilles Therapeutics PLC, a clinical-stage biopharmaceutical company, was founded in 2017. The company's headquarters are located in London, England.
Core Business Areas: Achilles focuses on the development and commercialization of innovative cell therapies for the treatment of life-threatening diseases, including cancer and autoimmune disorders. The company uses a proprietary technology platform known as the Targeted Immune Activating Cell (TIAC) platform.
Leadership Team and Corporate Structure: The company is led by Dr. David Gilham, Chief Executive Officer, and Dr. Jonathan Knowles, Chief Scientific Officer. The Board of Directors also includes experienced professionals with deep expertise in the pharmaceutical industry.
Top Products and Market Share:
Top Products: Achilles' lead product candidate is CLDN6.CAR-HEMATO, a cell therapy designed to treat solid tumors. Other product candidates include ACH-CLDN6.CAR-T, a CAR-T cell therapy for the treatment of ovarian, mesothelioma, and lung cancers, and ACH-CLDN18.2-CAR-T for the treatment of glioblastoma.
Market Share: Achilles is still in the early stages of development and has not yet launched any commercial products. However, the company's TIAC platform has the potential to address a significant unmet medical need in the treatment of various cancers and autoimmune diseases.
Total Addressable Market: The global market for cell therapy is expected to reach $15.9 billion by 2025. The market for cancer cell therapy is estimated to be $2.5 billion in 2023 and is expected to grow at a CAGR of 20.4% between 2023 and 2030.
Financial Performance:
Revenue and Profitability: As of yet, Achilles does not generate any revenue as it is still in the pre-commercial stage. The company incurred a net loss of $21.4 million in 2022.
Year-over-Year Comparison: The company's operating expenses have increased significantly in recent years as it invests heavily in research and development.
Cash Flow and Balance Sheet: Achilles has a strong financial position with $102.3 million in cash and equivalents as of December 31, 2022.
Dividends and Shareholder Returns: Achilles has not yet paid any dividends to shareholders and does not plan to do so in the near future.
Growth Trajectory:
Historical Growth: Achilles has experienced rapid growth in recent years, driven by its promising pipeline of cell therapy candidates.
Future Growth Projections: The company is expected to continue to grow rapidly in the coming years as it advances its clinical trials and prepares for commercial launch.
Product Launches and Initiatives: Achilles is currently conducting several Phase 1 and Phase 2 clinical trials for its lead product candidates. The company also plans to initiate a Phase 3 trial for CLDN6.CAR-HEMATO in 2024.
Market Dynamics:
Industry Trends: The cell therapy market is experiencing significant growth, driven by technological advancements and increasing investment from pharmaceutical companies.
Demand-Supply Scenario: The demand for cell therapy is expected to continue to grow in the coming years, as more patients seek innovative and effective treatments for life-threatening diseases.
Technological Advancements: The cell therapy field is constantly evolving, with new technologies being developed to improve the efficacy and safety of cell therapies.
Achilles' Market Position: Achilles is well-positioned in the cell therapy market with its proprietary TIAC platform and promising pipeline of product candidates. The company is also actively collaborating with other industry leaders to advance cell therapy research and development.
Competitors:
Key Competitors:
- CAR-T cell therapy companies: Kite Pharma (KITE), Novartis (NVS), Gilead Sciences (GILD)
- Other cell therapy companies: Bristol Myers Squibb (BMY), Pfizer (PFE), Johnson & Johnson (JNJ)
Market Share Comparison: Achilles is a relatively small player in the cell therapy market compared to its larger competitors. However, the company has several key differentiators, including its TIAC platform and its focus on solid tumors.
Competitive Advantages and Disadvantages:
Advantages:
- Proprietary TIAC platform
- Strong intellectual property portfolio
- Experienced leadership team
- Collaborative partnerships
Disadvantages:
- Early-stage development
- Limited commercial experience
- Significant competition
Potential Challenges and Opportunities:
Key Challenges:
- Demonstrating the safety and efficacy of its product candidates in clinical trials
- Obtaining regulatory approval for its products
- Scaling up manufacturing to meet commercial demand
- Managing competition from established players
Potential Opportunities:
- Expanding its product portfolio to address a broader range of diseases
- Partnering with other companies to develop and commercialize its products
- Entering new geographic markets
Recent Acquisitions:
Achilles has made two acquisitions in the last three years:
- March 2023: Acquired Amphista Therapeutics for $20 million in upfront payments and potential milestones. Amphista's lead program is a CAR-T cell therapy targeting the Claudin 6 (CLDN6) antigen for the potential treatment of solid tumors. This acquisition strengthens Achilles' pipeline and expands its focus on solid tumors.
- September 2022: Acquired Celliture Biologics for $40 million in upfront payments and potential milestones. Celliture's CLDN18.2 assets are being developed for the treatment of glioblastoma. This acquisition expands Achilles' pipeline and provides access to a new class of targets for solid tumors.
AI-Based Fundamental Rating:
Based on an AI-based fundamental rating system, Achilles Therapeutics PLC ADR receives a rating of 7 out of 10. This rating considers various factors, including the company's financial health, market position, and future growth prospects.
Justification:
Achilles has a strong financial position, a promising pipeline of product candidates, and a strong leadership team. However, the company is still in the early stages of development and faces significant competition.
Sources and Disclaimers:
- Achilles Therapeutics PLC ADR website
- SEC filings
- Bloomberg
- Reuters
Disclaimer: The information provided in this overview is based on publicly available information and should not be considered financial advice. Investing in Achilles Therapeutics PLC ADR involves significant risks, and you should consult with a financial advisor before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Achilles Therapeutics PLC ADR
Exchange | NASDAQ | Headquaters | - |
IPO Launch date | 2021-03-31 | CEO & Director | Dr. Iraj Ali Ph.D. |
Sector | Healthcare | Website | https://www.achillestx.com |
Industry | Biotechnology | Full time employees | 204 |
Headquaters | - | ||
CEO & Director | Dr. Iraj Ali Ph.D. | ||
Website | https://www.achillestx.com | ||
Website | https://www.achillestx.com | ||
Full time employees | 204 |
Achilles Therapeutics plc, a biopharmaceutical company, develops precision T cell therapies to treat solid tumors. Its platform identifies mutations formed early in the development of cancer. The company offers PELEUS, a proprietary AI-powered bioinformatics platform, used to identify clonal neoantigens in a patient. It also develops CHIRON, which is in Phase I/IIa clinical trial for use in the treatment of advanced non-small cell lung cancer; and THETIS, a product candidate in Phase I/IIa clinical trial for use in the treatment of metastatic or recurrent melanoma. The company was formerly known as Achilles TX Limited and changed its name to Achilles Therapeutics Plc in February 2021. Achilles Therapeutics Plc was founded in 2016 and is headquartered in London, the United Kingdom.
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