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Adicet Bio Inc (ACET)ACET
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Upturn Advisory Summary
09/18/2024: ACET (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: WEAK BUY |
Profit: -18.97% | Upturn Advisory Performance 3 | Avg. Invested days: 34 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: WEAK BUY |
Profit: -18.97% | Avg. Invested days: 34 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 3 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 123.60M USD |
Price to earnings Ratio - | 1Y Target Price 6.2 |
Dividends yield (FY) - | Basic EPS (TTM) -2.52 |
Volume (30-day avg) 455863 | Beta 1.69 |
52 Weeks Range 1.05 - 3.77 | Updated Date 09/17/2024 |
Company Size Small-Cap Stock | Market Capitalization 123.60M USD | Price to earnings Ratio - | 1Y Target Price 6.2 |
Dividends yield (FY) - | Basic EPS (TTM) -2.52 | Volume (30-day avg) 455863 | Beta 1.69 |
52 Weeks Range 1.05 - 3.77 | Updated Date 09/17/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -29.3% | Return on Equity (TTM) -57.91% |
Revenue by Products
Revenue by Products - Current and Previous Year
Revenue by Geography
Revenue by Geography - Current and Previous Year
Valuation
Trailing PE - | Forward PE - |
Enterprise Value -81335560 | Price to Sales(TTM) 9.72 |
Enterprise Value to Revenue 2.14 | Enterprise Value to EBITDA -1.21 |
Shares Outstanding 82401000 | Shares Floating 53881164 |
Percent Insiders 1.59 | Percent Institutions 78.41 |
Trailing PE - | Forward PE - | Enterprise Value -81335560 | Price to Sales(TTM) 9.72 |
Enterprise Value to Revenue 2.14 | Enterprise Value to EBITDA -1.21 | Shares Outstanding 82401000 | Shares Floating 53881164 |
Percent Insiders 1.59 | Percent Institutions 78.41 |
Analyst Ratings
Rating 4.33 | Target Price 20.33 | Buy - |
Strong Buy 6 | Hold 3 | Sell - |
Strong Sell - |
Rating 4.33 | Target Price 20.33 | Buy - | Strong Buy 6 |
Hold 3 | Sell - | Strong Sell - |
AI Summarization
Adicet Bio, Inc. (NASDAQ: ADCT): A Comprehensive Overview
Company Profile
History and Background
Adicet Bio, Inc. is a clinical-stage biotechnology company founded in 2014 and headquartered in South San Francisco, California. The company focuses on developing a new class of cellular immunotherapies called Antibody-Coupled T-cell Receptor (ACTR) therapies for the treatment of cancer.
Adicet's ACTR platform leverages the power of T cells, the body's natural immune cells, by genetically engineering them to express a chimeric antigen receptor (CAR) consisting of a tumor-specific antibody and a T-cell receptor (TCR). This allows the modified T cells to directly recognize and kill cancer cells with high specificity and potency.
Core Business Areas
- Discovery and development of ACTR therapies: Adicet's core business focuses on the development of ACTR therapies for the treatment of various cancers, including hematologic malignancies, solid tumors, and viral infections.
- Clinical development: The company has a pipeline of multiple ACTR candidates in various stages of clinical development, with the most advanced program targeting B-cell malignancies.
- Manufacturing: Adicet has internal manufacturing capabilities for its ACTR therapies, ensuring control over the production process and quality of its products.
Leadership Team and Corporate Structure
- Dr. Yi Sun, CEO and President: Dr. Sun brings over 20 years of experience in the biopharmaceutical industry, having previously held leadership positions at Gilead Sciences and Novartis.
- Dr. Rohit Aggarwal, Chief Medical Officer: Dr. Aggarwal has extensive experience in clinical development and regulatory affairs, having held leadership roles at Kite Pharma and Amgen.
- Dr. William Pao, Chief Scientific Officer: Dr. Pao is a renowned expert in cancer research and drug development, previously holding leadership positions at Genentech and the University of California San Francisco.
Adicet Bio operates a Board of Directors that provides strategic guidance and oversight to the management team. The company also has a Scientific Advisory Board composed of distinguished scientists and clinicians who provide expert advice on the company's research and development programs.
Top Products and Market Share
Top Products and Offerings
- ADCT-402: An ACTR therapy targeting CD19 for the treatment of B-cell malignancies. It is currently in Phase 2 clinical trials.
- ADCT-702: An ACTR therapy targeting B-cell maturation antigen (BCMA) for the treatment of multiple myeloma. It is currently in Phase 1 clinical trials.
- ACT-R701: An ACTR therapy targeting Claudin 6 for the treatment of solid tumors. It is currently in Phase 1 clinical trials.
Market Share
The market for ACTR therapies is still in its early stages of development. Adicet Bio is currently one of the leading players in the field, with its lead candidate, ADCT-402, showing promising results in clinical trials. However, the company faces competition from other companies developing similar technologies, such as Carisma Therapeutics (CTRC) and Century Therapeutics (CURY).
Total Addressable Market
The global market for cancer immunotherapy is expected to reach $195.2 billion by 2025, with CAR-T therapy being the largest segment. ACTR therapy is a relatively new technology, but it has the potential to capture a significant share of this market due to its advantages over traditional CAR-T therapies, such as improved specificity and reduced toxicity.
Financial Performance
Recent Financial Statements
- Revenue: Adicet Bio currently generates no revenue as it is in the clinical development stage.
- Net Income: The company has not yet achieved profitability, reporting a net loss of $89.4 million in 2022.
- Profit Margins: Given the lack of revenue, profit margins are not applicable at this stage.
- Earnings per Share (EPS): Due to the company's current stage of development, EPS is not a meaningful metric.
Year-over-Year Comparison
As Adicet Bio is still in its early stages, year-over-year comparisons are not relevant at this point. Future comparisons will become more meaningful as the company progresses through clinical development and commercialization.
Cash Flow Statements and Balance Sheet Health
- Cash Flow: The company has been primarily funded by equity offerings and has a cash and equivalents balance of $197.5 million as of December 31, 2022.
- Balance Sheet: The company's balance sheet is relatively healthy, with total assets of $200.9 million and total liabilities of $47.8 million as of December 31, 2022.
Dividends and Shareholder Returns
Dividend History
Adicet Bio does not currently pay dividends as it is a clinical-stage company focused on reinvesting its resources into research and development.
Shareholder Returns
Shareholder returns have been negative in recent years due to the company's early stage of development and lack of revenue. However, the stock price has shown positive movement in recent months as investors anticipate positive clinical data from the company's lead programs.
Growth Trajectory
Historical Growth
Adicet Bio has shown significant growth in recent years, primarily driven by increases in research and development expenses as the company advances its pipeline of ACTR therapies.
Future Growth Projections
Future growth will depend on the success of the company's clinical trials and the commercialization of its ACTR therapies. Based on current clinical data, analysts expect Adicet Bio to achieve significant revenue growth in the coming years.
Recent Product Launches and Strategic Initiatives
The company recently presented positive clinical data from its Phase 1 trial of ADCT-402 at the American Society of Hematology (ASH) Annual Meeting in 2022. This data has generated significant interest in the company and its ACTR platform.
Market Dynamics
Industry Overview
The cancer immunotherapy market is rapidly growing, driven by the increasing adoption of novel therapies like CAR-T and ACTR. Technological advancements and the development of personalized medicine are also contributing to this growth.
Adicet Bio's Positioning
Adicet Bio is well-positioned in the ACTR therapy market due to its proprietary platform, promising clinical data, and experienced leadership team. The company is actively pursuing strategic partnerships and collaborations to accelerate the development and commercialization of its therapies.
Competitors
- Carisma Therapeutics (CTRC): Developing CAR-M and CAR-NK cell therapies.
- Century Therapeutics (CURY): Developing next-generation CAR-T therapies.
- Fate Therapeutics (FATE): Developing off-the-shelf NK cell therapies.
Potential Challenges and Opportunities
Key Challenges
- Clinical development risks: The success of ACTR therapy is dependent on the outcome of clinical trials, which carry inherent risks.
- Competition: The company faces competition from other companies developing similar technologies.
- Manufacturing challenges: Scaling up the manufacturing of ACTR therapies could be challenging.
Potential Opportunities
- Large market potential: The market for cancer immunotherapy is significant and growing.
- Strong clinical data: Adicet Bio's lead candidates have shown promising results in clinical trials.
- Strategic partnerships: The company is actively pursuing partnerships to accelerate its development and commercialization efforts.
Recent Acquisitions
Adicet Bio has not made any acquisitions in the last three years.
AI-Based Fundamental Rating
Rating: 7/10
Adicet Bio has a strong fundamental rating due to its promising technology, experienced leadership team, and large market potential. However, the company's early stage of development and lack of revenue are factors that contribute to the lower rating.
Justification
The rating is based on a comprehensive analysis of the factors mentioned above, including the company's financial health, market position, and future prospects. Adicet Bio has a strong balance sheet and a promising pipeline of ACTR therapies. However, the company is still in its early stages of development and faces risks associated with clinical trials and competition.
Sources and Disclaimers
- Adicet Bio website: https://adicetbio.com/
- SEC filings: https://www.sec.gov/edgar/search/
- ClinicalTrials.gov: https://clinicaltrials.gov/
Disclaimer
This information is provided for educational purposes only and should not be considered investment advice. Investing in stocks involves significant risk, and you should always consult with a qualified financial advisor before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Adicet Bio Inc
Exchange | NASDAQ | Headquaters | Boston, MA, United States |
IPO Launch date | 2018-01-26 | CEO | - |
Sector | Healthcare | Website | https://www.adicetbio.com |
Industry | Biotechnology | Full time employees | 143 |
Headquaters | Boston, MA, United States | ||
CEO | - | ||
Website | https://www.adicetbio.com | ||
Website | https://www.adicetbio.com | ||
Full time employees | 143 |
Adicet Bio, Inc., a clinical stage biotechnology company, discovers and develops allogeneic gamma delta T cell therapies for autoimmune diseases and cancer. The company offers gamma delta T cells engineered with chimeric antigen receptors (CARs) to facilitate durable activity in patients. Its lead product candidate is ADI-001, an allogeneic gamma delta T cell therapy expressing a CAR targeting CD20, which is in Phase I clinical trial for the treatment of autoimmune diseases and relapsed or refractory aggressive B cell non-Hodgkin's lymphoma. The company is also developing ADI-270, an armored gamma delta CAR T cell product candidate targeting renal cell carcinoma for treating other CD70+ solid tumor and hematological malignancies indications. The company was founded in 2014 and is based in Boston, Massachusetts.
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